1hv7
From Proteopedia
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|PDB= 1hv7 |SIZE=350|CAPTION= <scene name='initialview01'>1hv7</scene>, resolution 1.7Å | |PDB= 1hv7 |SIZE=350|CAPTION= <scene name='initialview01'>1hv7</scene>, resolution 1.7Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=616:N-[2-(1-FORMYL-2-METHYL-PROPYL)-1-(4-PIPERIDIN-1-YL-BUT-2-ENOYL)-PYRROLIDIN-3-YL]-METHANESULFONAMIDE'>616</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hv7 OCA], [http://www.ebi.ac.uk/pdbsum/1hv7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1hv7 RCSB]</span> | ||
}} | }} | ||
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[[Category: Singh, O M.]] | [[Category: Singh, O M.]] | ||
[[Category: Skarzynski, T.]] | [[Category: Skarzynski, T.]] | ||
| - | [[Category: 616]] | ||
| - | [[Category: SO4]] | ||
[[Category: serine protease-inhibitor complex]] | [[Category: serine protease-inhibitor complex]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:10:54 2008'' |
Revision as of 18:10, 30 March 2008
| |||||||
| , resolution 1.7Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Activity: | Pancreatic elastase, with EC number 3.4.21.36 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
PORCINE PANCREATIC ELASTASE COMPLEXED WITH GW311616A
Overview
The discovery of a potent intracellular inhibitor of human neutrophil elastase which is orally active and has a long duration of action is described. The pharmacodynamic and pharmacokinetic properties of a trans-lactam development candidate, GW311616A, are described.
About this Structure
1HV7 is a Single protein structure of sequence from Sus scrofa. Full crystallographic information is available from OCA.
Reference
The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase--GW311616A a development candidate., Macdonald SJ, Dowle MD, Harrison LA, Shah P, Johnson MR, Inglis GG, Clarke GD, Smith RA, Humphreys D, Molloy CR, Amour A, Dixon M, Murkitt G, Godward RE, Padfield T, Skarzynski T, Singh OM, Kumar KA, Fleetwood G, Hodgson ST, Hardy GW, Finch H, Bioorg Med Chem Lett. 2001 Apr 9;11(7):895-8. PMID:11294386
Page seeded by OCA on Sun Mar 30 21:10:54 2008
