1i05
From Proteopedia
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|PDB= 1i05 |SIZE=350|CAPTION= <scene name='initialview01'>1i05</scene>, resolution 2.0Å | |PDB= 1i05 |SIZE=350|CAPTION= <scene name='initialview01'>1i05</scene>, resolution 2.0Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene> | + | |LIGAND= <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=LTL:6-HYDROXY-6-METHYL-HEPTAN-3-ONE'>LTL</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= MUP-I ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | |GENE= MUP-I ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1mup|1MUP]], [[1io4|1IO4]], [[1io6|1IO6]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i05 OCA], [http://www.ebi.ac.uk/pdbsum/1i05 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1i05 RCSB]</span> | ||
}} | }} | ||
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[[Category: Timm, D E.]] | [[Category: Timm, D E.]] | ||
[[Category: Zidek, L.]] | [[Category: Zidek, L.]] | ||
| - | [[Category: CD]] | ||
| - | [[Category: LTL]] | ||
[[Category: beta-barrel]] | [[Category: beta-barrel]] | ||
[[Category: lipocalin]] | [[Category: lipocalin]] | ||
[[Category: pheromone]] | [[Category: pheromone]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:12:44 2008'' |
Revision as of 18:12, 30 March 2008
| |||||||
| , resolution 2.0Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Gene: | MUP-I (Mus musculus) | ||||||
| Related: | 1MUP, 1IO4, 1IO6
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF MOUSE MAJOR URINARY PROTEIN (MUP-I) COMPLEXED WITH HYDROXY-METHYL-HEPTANONE
Overview
The mouse major urinary proteins are pheromone-binding proteins that function as carriers of volatile effectors of mouse physiology and behavior. Crystal structures of recombinant mouse major urinary protein-I (MUP-I) complexed with the synthetic pheromones, 2-sec-butyl-4,5-dihydrothiazole and 6-hydroxy-6-methyl-3-heptanone, have been determined at high resolution. The purification of MUP-I from mouse liver and a high-resolution structure of the natural isolate are also reported. These results show the binding of 6-hydroxy-6-methyl-3-heptanone to MUP-I, unambiguously define ligand orientations for two pheromones within the MUP-I binding site, and suggest how different chemical classes of pheromones can be accommodated within the MUP-I beta-barrel.
About this Structure
1I05 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Structural basis of pheromone binding to mouse major urinary protein (MUP-I)., Timm DE, Baker LJ, Mueller H, Zidek L, Novotny MV, Protein Sci. 2001 May;10(5):997-1004. PMID:11316880
Page seeded by OCA on Sun Mar 30 21:12:44 2008
