5boa
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of the Meningitis Pathogen Streptococcus suis adhesion Fhb bound to the disaccharide receptor Gb2== | |
| + | <StructureSection load='5boa' size='340' side='right' caption='[[5boa]], [[Resolution|resolution]] 2.71Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5boa]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BOA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BOA FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5bob|5bob]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5boa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5boa OCA], [http://pdbe.org/5boa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5boa RCSB], [http://www.ebi.ac.uk/pdbsum/5boa PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The recently identified Streptococcus suis adhesin Fhb targets the host cellular receptor glycolipid GbO3 through its N-terminus. However, it is unclear how Fhb interacts with its receptor. Here, we determined the complex structure of Fhb RBD with Gb2, an analog of its receptor, revealing that Gb2 binds in a pocket of the beta sandwich core domain. We identified the key residues for Fhb RBD receptor binding using mutagenesis and isothermal titration calorimetry. Mutagenesis analyses indicated that Fhb binds to Gb2 mainly through hydrogen and hydrophobic interactions. Our findings provided structural insights into the Fhb-mediated host-pathogen interactions of S. suis. This article is protected by copyright. All rights reserved. | ||
| - | + | Structural Basis of the Interaction between the Meningitis Pathogen Streptococcus suis Adhesin Fhb and its Human Receptor.,Zhang C, Hao H, Yu Y, Kong D, Chen S, Jiang H, Yuan Y, Zheng Y, Yang M, Jiang Y FEBS Lett. 2016 Apr 17. doi: 10.1002/1873-3468.12174. PMID:27086582<ref>PMID:27086582</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 5boa" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Jiang, Y]] | ||
[[Category: Yang, M]] | [[Category: Yang, M]] | ||
[[Category: Yu, Y]] | [[Category: Yu, Y]] | ||
| - | [[Category: Jiang, Y]] | ||
[[Category: Zhang, C]] | [[Category: Zhang, C]] | ||
| + | [[Category: Protein-polysaccharide complex]] | ||
| + | [[Category: Sugar binding protein]] | ||
Revision as of 03:38, 11 May 2016
Crystal Structure of the Meningitis Pathogen Streptococcus suis adhesion Fhb bound to the disaccharide receptor Gb2
| |||||||||||
