4uc4
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of hybrid tudor domain of human lysine demethylase KDM4B== | |
| + | <StructureSection load='4uc4' size='340' side='right' caption='[[4uc4]], [[Resolution|resolution]] 2.56Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4uc4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UC4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UC4 FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uc4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uc4 OCA], [http://pdbe.org/4uc4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uc4 RCSB], [http://www.ebi.ac.uk/pdbsum/4uc4 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/KDM4B_HUMAN KDM4B_HUMAN]] Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.<ref>PMID:16603238</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Jumonji domain-containing protein|Jumonji domain-containing protein]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: G | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Denu, J M]] | ||
| + | [[Category: Phillips, G N]] | ||
[[Category: Su, Z]] | [[Category: Su, Z]] | ||
| - | [[Category: Denu, J.M]] | ||
[[Category: Wang, F]] | [[Category: Wang, F]] | ||
| - | [[Category: | + | [[Category: Chromatin]] |
| + | [[Category: Replication]] | ||
| + | [[Category: Tudor]] | ||
Revision as of 03:42, 11 May 2016
Crystal structure of hybrid tudor domain of human lysine demethylase KDM4B
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Categories: Denu, J M | Phillips, G N | Su, Z | Wang, F | Chromatin | Replication | Tudor
