This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5a28
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Leishmania major N-myristoyltransferase in complex with a chlorophenyl inhibitor (compound 13).== | |
| + | <StructureSection load='5a28' size='340' side='right' caption='[[5a28]], [[Resolution|resolution]] 1.48Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5a28]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A28 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A28 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MYA:TETRADECANOYL-COA'>MYA</scene>, <scene name='pdbligand=TUQ:4-(4-CHLORO-2-{5-[(TRIMETHYL-1H-PYRAZOL-4-YL)METHYL]-1,3,4-OXADIAZOL-2-YL}PHENOXY)PIPERIDINE'>TUQ</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5a27|5a27]]</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a28 OCA], [http://pdbe.org/5a28 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a28 RCSB], [http://www.ebi.ac.uk/pdbsum/5a28 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/Q4Q5S8_LEIMA Q4Q5S8_LEIMA]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity). | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | N-Myristoyltransferase (NMT) is a potential drug target in Leishmania parasites. Scaffold-hopping from published inhibitors yielded the serendipitous discovery of a chemotype selective for Leishmania donovani NMT; development led to high affinity inhibitors with excellent ligand efficiency. The binding mode was characterised by crystallography and provides a structural rationale for selectivity. | ||
| - | + | Discovery of high affinity inhibitors of -myristoyltransferase.,Rackham MD, Yu Z, Brannigan JA, Heal WP, Paape D, Barker KV, Wilkinson AJ, Smith DF, Leatherbarrow RJ, Tate EW Medchemcomm. 2015 Oct 8;6(10):1761-1766. Epub 2015 Aug 19. PMID:26962429<ref>PMID:26962429</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 5a28" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Glycylpeptide N-tetradecanoyltransferase]] | ||
| + | [[Category: Barker, K V]] | ||
| + | [[Category: Brannigan, J A]] | ||
| + | [[Category: Heal, W P]] | ||
| + | [[Category: Leatherbarrow, R J]] | ||
[[Category: Paape, D]] | [[Category: Paape, D]] | ||
| + | [[Category: Rackham, M D]] | ||
| + | [[Category: Smith, D F]] | ||
| + | [[Category: Tate, E W]] | ||
| + | [[Category: Wilkinson, A J]] | ||
[[Category: Yu, Z]] | [[Category: Yu, Z]] | ||
| - | [[Category: | + | [[Category: Drug design]] |
| - | [[Category: | + | [[Category: Inhibitor]] |
| - | [[Category: | + | [[Category: Myristoylation]] |
| - | [[Category: | + | [[Category: Transferase]] |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Revision as of 12:58, 11 May 2016
Leishmania major N-myristoyltransferase in complex with a chlorophenyl inhibitor (compound 13).
| |||||||||||
