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1i7w

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|PDB= 1i7w |SIZE=350|CAPTION= <scene name='initialview01'>1i7w</scene>, resolution 2.00&Aring;
|PDB= 1i7w |SIZE=350|CAPTION= <scene name='initialview01'>1i7w</scene>, resolution 2.00&Aring;
|SITE=
|SITE=
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=CL:CHLORIDE ION'>CL</scene>
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
|ACTIVITY=
|ACTIVITY=
|GENE= CATNB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), CDH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
|GENE= CATNB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), CDH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
 +
|DOMAIN=
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|RELATEDENTRY=[[1i7x|1I7X]], [[2bct|2bct]], [[3bct|3bct]], [[1g3j|1G3J]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i7w OCA], [http://www.ebi.ac.uk/pdbsum/1i7w PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1i7w RCSB]</span>
}}
}}
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[[Category: Huber, A H.]]
[[Category: Huber, A H.]]
[[Category: Weis, W I.]]
[[Category: Weis, W I.]]
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[[Category: CL]]
 
-
[[Category: ZN]]
 
[[Category: armadillo repeat]]
[[Category: armadillo repeat]]
[[Category: beta-catenin]]
[[Category: beta-catenin]]
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[[Category: protein-protein complex]]
[[Category: protein-protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:46:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:15:51 2008''

Revision as of 18:15, 30 March 2008

Image:1i7w.gif


PDB ID 1i7w

Drag the structure with the mouse to rotate
, resolution 2.00Å
Ligands: , ,
Gene: CATNB (Mus musculus), CDH1 (Mus musculus)
Related: 1I7X, 2bct, 3bct, 1G3J


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



BETA-CATENIN/PHOSPHORYLATED E-CADHERIN COMPLEX


Overview

As a component of adherens junctions and the Wnt signaling pathway, beta-catenin binds cadherins, Tcf family transcription factors, and the tumor suppressor APC. We have determined the crystal structures of both unphosphorylated and phosphorylated E-cadherin cytoplasmic domain complexed with the arm repeat region of beta-catenin. The interaction spans all 12 arm repeats, and features quasi-independent binding regions that include helices which interact with both ends of the arm repeat domain and an extended stretch of 14 residues which closely resembles a portion of XTcf-3. Phosphorylation of E-cadherin results in interactions with a hydrophobic patch of beta-catenin that mimics the binding of an amphipathic XTcf-3 helix. APC contains sequences homologous to the phosphorylated region of cadherin, and is likely to bind similarly.

About this Structure

1I7W is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin., Huber AH, Weis WI, Cell. 2001 May 4;105(3):391-402. PMID:11348595

Page seeded by OCA on Sun Mar 30 21:15:51 2008

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