5hrt

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'''Unreleased structure'''
 
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The entry 5hrt is ON HOLD until Paper Publication
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==Crystal structure of mouse autotaxin in complex with a DNA aptamer==
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<StructureSection load='5hrt' size='340' side='right' caption='[[5hrt]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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Authors: Kato, K., Nishimasu, H., Morita, J., Ishitani, R., Nureki, O.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5hrt]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HRT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HRT FirstGlance]. <br>
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Description: Crystal structure of mouse autotaxin in complex with a DNA aptamer
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2M:2-O-METHYLADENOSINE+5-(DIHYDROGEN+PHOSPHATE)'>A2M</scene>, <scene name='pdbligand=OMC:O2-METHYLYCYTIDINE-5-MONOPHOSPHATE'>OMC</scene>, <scene name='pdbligand=OMG:O2-METHYLGUANOSINE-5-MONOPHOSPHATE'>OMG</scene></td></tr>
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[[Category: Nureki, O]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alkylglycerophosphoethanolamine_phosphodiesterase Alkylglycerophosphoethanolamine phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.39 3.1.4.39] </span></td></tr>
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[[Category: Nishimasu, H]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hrt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hrt OCA], [http://pdbe.org/5hrt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hrt RCSB], [http://www.ebi.ac.uk/pdbsum/5hrt PDBsum]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/ENPP2_MOUSE ENPP2_MOUSE]] Note=May contribute to obesity.
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== Function ==
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[[http://www.uniprot.org/uniprot/ENPP2_MOUSE ENPP2_MOUSE]] Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor.<ref>PMID:15700135</ref> <ref>PMID:17208043</ref> <ref>PMID:21240269</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Alkylglycerophosphoethanolamine phosphodiesterase]]
[[Category: Ishitani, R]]
[[Category: Ishitani, R]]
[[Category: Kato, K]]
[[Category: Kato, K]]
[[Category: Morita, J]]
[[Category: Morita, J]]
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[[Category: Nishimasu, H]]
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[[Category: Nureki, O]]
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[[Category: Dna aptamer]]
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[[Category: Hydrolase]]
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[[Category: Phospholipase d]]

Revision as of 04:11, 12 May 2016

Crystal structure of mouse autotaxin in complex with a DNA aptamer

5hrt, resolution 2.00Å

Drag the structure with the mouse to rotate

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