2n82
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==solution structure of the complex of microRNA 20b pre-element with Rbfox RRM== | |
| + | <StructureSection load='2n82' size='340' side='right' caption='[[2n82]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2n82]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N82 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N82 FirstGlance]. <br> | ||
| + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2n7x|2n7x]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n82 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n82 OCA], [http://pdbe.org/2n82 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n82 RCSB], [http://www.ebi.ac.uk/pdbsum/2n82 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/RFOX1_HUMAN RFOX1_HUMAN]] RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis.<ref>PMID:16537540</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Rbfox proteins regulate tissue-specific splicing by targeting a conserved GCAUG sequence within pre-mRNAs. We report here that sequence-specific binding of the conserved Rbfox RRM to miRNA precursors containing the same sequence motif in their terminal loops, including miR-20b and miR-107, suppresses their nuclear processing. The structure of the complex between precursor miR-20b and Rbfox RRM shows the molecular basis for recognition, and reveals changes in the stem-loop upon protein binding. In mammalian cells, Rbfox2 downregulates mature miR-20b and miR-107 levels and increases the expression of their downstream targets PTEN and Dicer, respectively, suggesting that Rbfox2 indirectly regulates many more cellular miRNAs. Thus, some of the widespread cellular functions of Rbfox2 protein are attributable to regulation of miRNA biogenesis, and might include the mis-regulation of miR-20b and miR-107 in cancer and neurodegeneration. | ||
| - | + | Rbfox proteins regulate microRNA biogenesis by sequence-specific binding to their precursors and target downstream Dicer.,Chen Y, Zubovic L, Yang F, Godin K, Pavelitz T, Castellanos J, Macchi P, Varani G Nucleic Acids Res. 2016 Mar 21. pii: gkw177. PMID:27001519<ref>PMID:27001519</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 2n82" style="background-color:#fffaf0;"></div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Chen, Y]] | [[Category: Chen, Y]] | ||
| + | [[Category: Varani, G]] | ||
[[Category: Yang, F]] | [[Category: Yang, F]] | ||
| + | [[Category: Microrna]] | ||
| + | [[Category: Rbfox]] | ||
| + | [[Category: Rna binding protein-rna complex]] | ||
| + | [[Category: Rrm]] | ||
Revision as of 11:15, 12 May 2016
solution structure of the complex of microRNA 20b pre-element with Rbfox RRM
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Categories: Chen, Y | Varani, G | Yang, F | Microrna | Rbfox | Rna binding protein-rna complex | Rrm
