4uhj

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'''Unreleased structure'''
 
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The entry 4uhj is ON HOLD until Paper Publication
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==Crystal structure of the receiver domain of CpxR from E. coli (orthorhombic form)==
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<StructureSection load='4uhj' size='340' side='right' caption='[[4uhj]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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Authors: Mechaly, A.E., Alzari, P.M.A.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4uhj]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UHJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UHJ FirstGlance]. <br>
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Description: Crystal structure of the receiver domain of CpxR from E. coli ( orthorhombic form)
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uhk|4uhk]], [[4uhs|4uhs]], [[4uht|4uht]]</td></tr>
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[[Category: Alzari, P.M.A]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uhj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uhj OCA], [http://pdbe.org/4uhj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4uhj RCSB], [http://www.ebi.ac.uk/pdbsum/4uhj PDBsum]</span></td></tr>
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[[Category: Mechaly, A.E]]
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/CPXR_ECOLI CPXR_ECOLI]] Response regulator member of the two-component regulatory system CpxA/CpxR which responds to envelope stress response by activating expression of downstream genes including cpxP, degP, dsbA and ppiA (PubMed:7883164, PubMed:9401031). Binds and activates transcription from the degP promoter (PubMed:7883164); binding is enhanced by phosphorylation (PubMed:9401031). This system combats a variety of extracytoplasmic protein-mediated toxicities by increasing the transcription of the periplasmic protease, DegP in concert with sigma factor E (PubMed:7883164), as well as that of CpxP protein. Other downstream effectors may include SrkA (PubMed:23416055).<ref>PMID:23416055</ref> <ref>PMID:7883164</ref> <ref>PMID:9401031</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Alzari, P M.A]]
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[[Category: Mechaly, A E]]
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[[Category: Transcription]]

Revision as of 11:16, 12 May 2016

Crystal structure of the receiver domain of CpxR from E. coli (orthorhombic form)

4uhj, resolution 1.90Å

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