4ui4

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "4ui4" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 4ui4 is ON HOLD until Paper Publication
+
==Crystal structure of human tankyrase 2 in complex with TA-29==
-
 
+
<StructureSection load='4ui4' size='340' side='right' caption='[[4ui4]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-
Authors: Haikarainen, T., Lehtio, L.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[4ui4]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UI4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UI4 FirstGlance]. <br>
-
Description: Crystal structure of human tankyrase 2 in complex with TA-29
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RJN:BENZYL+N-{[4-(4-OXO-3,4-DIHYDROQUINAZOLIN-2-YL)PHENYL]METHYL}CARBAMATE'>RJN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ufy|4ufy]], [[4uhg|4uhg]], [[4ui3|4ui3]], [[4ui5|4ui5]], [[4ui6|4ui6]], [[4ui7|4ui7]], [[4ui8|4ui8]]</td></tr>
 +
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ui4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ui4 OCA], [http://pdbe.org/4ui4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ui4 RCSB], [http://www.ebi.ac.uk/pdbsum/4ui4 PDBsum]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Haikarainen, T]]
[[Category: Lehtio, L]]
[[Category: Lehtio, L]]
-
[[Category: Haikarainen, T]]
+
[[Category: Adp- ribosylation]]
 +
[[Category: Diphtheria toxin like fold]]
 +
[[Category: Protein-ligand complex]]
 +
[[Category: Transferase]]
 +
[[Category: Transferase-transferase inhibitor complex]]

Revision as of 11:17, 12 May 2016

Crystal structure of human tankyrase 2 in complex with TA-29

4ui4, resolution 2.40Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4ui4"
Personal tools