4ui8

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m (Protected "4ui8" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 4ui8 is ON HOLD until Paper Publication
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==Crystal structure of human tankyrase 2 in complex with TA-55==
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<StructureSection load='4ui8' size='340' side='right' caption='[[4ui8]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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Authors: Haikarainen, T., Lehtio, L.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ui8]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UI8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UI8 FirstGlance]. <br>
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Description: Crystal structure of human tankyrase 2 in complex with TA-55
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IY5:8-HYDROXY-2-[4-(TRIFLUOROMETHYL)PHENYL]-3,4-DIHYDROQUINAZOLIN-4-ONE'>IY5</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ufy|4ufy]], [[4uhg|4uhg]], [[4ui3|4ui3]], [[4ui4|4ui4]], [[4ui5|4ui5]], [[4ui6|4ui6]], [[4ui7|4ui7]]</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ui8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ui8 OCA], [http://pdbe.org/4ui8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ui8 RCSB], [http://www.ebi.ac.uk/pdbsum/4ui8 PDBsum]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Haikarainen, T]]
[[Category: Lehtio, L]]
[[Category: Lehtio, L]]
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[[Category: Haikarainen, T]]
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[[Category: Adp- ribosylation]]
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[[Category: Diphtheria toxin like fold]]
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[[Category: Protein-ligand complex]]
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[[Category: Transferase]]
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[[Category: Transferase-transferase inhibitor complex]]

Revision as of 11:17, 12 May 2016

Crystal structure of human tankyrase 2 in complex with TA-55

4ui8, resolution 2.05Å

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