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4z2z
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==New crystal structure of yeast Ddi1 aspartyl protease reveals substrate engagement mode== | |
| - | + | <StructureSection load='4z2z' size='340' side='right' caption='[[4z2z]], [[Resolution|resolution]] 1.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4z2z]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z2Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z2Z FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z2z OCA], [http://pdbe.org/4z2z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z2z RCSB], [http://www.ebi.ac.uk/pdbsum/4z2z PDBsum]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DDI1_YEAST DDI1_YEAST]] Acts as a linker between the 19S proteasome and polyubiquitinated proteins like the HO endonuclease and UFO1 via UBA domain interactions with ubiquitin for their subsequent degradation. Required for S-phase checkpoint control. Appears to act as negative regulator of constitutive exocytosis. May act at the level of secretory vesicle docking and fusion as a competitive inhibitor of SNARE assembly.<ref>PMID:10330187</ref> <ref>PMID:11238935</ref> <ref>PMID:12051757</ref> <ref>PMID:12925750</ref> <ref>PMID:15964793</ref> <ref>PMID:17144915</ref> <ref>PMID:16478980</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Feng, X]] | ||
[[Category: Gehring, K]] | [[Category: Gehring, K]] | ||
| - | [[Category: Trempe, J | + | [[Category: Trempe, J F]] |
| - | [[Category: | + | [[Category: Ddi1]] |
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Protease]] | ||
Revision as of 11:19, 12 May 2016
New crystal structure of yeast Ddi1 aspartyl protease reveals substrate engagement mode
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Categories: Feng, X | Gehring, K | Trempe, J F | Ddi1 | Hydrolase | Protease
