4z44

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'''Unreleased structure'''
 
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The entry 4z44 is ON HOLD
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==F454K Mutant of Tryptophan 7-halogenase PrnA==
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<StructureSection load='4z44' size='340' side='right' caption='[[4z44]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4z44]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z44 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z44 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4z43|4z43]]</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptophan_7-halogenase Tryptophan 7-halogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.19.9 1.14.19.9] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z44 OCA], [http://pdbe.org/4z44 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z44 RCSB], [http://www.ebi.ac.uk/pdbsum/4z44 PDBsum]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/PRNA_PSEFL PRNA_PSEFL]] Involved in the biosynthesis of the antifungal antibiotic pyrrolnitrin. Catalyze the chlorination of tryptophan (Trp) at C7 position to yield 7-chloro-L-tryptophan (7-CLT). The reaction between FADH2, Cl-, and O2 generates the powerful oxidant HOCl, which is presumed to carry out the chlorination reaction. The reaction of HOCl with the active site Lys-79 generates a lysine chloramine, which plays a key role in directing regiospecific chlorination of substrate in this important class of biosynthetic enzymes. It is also able to use bromide ions to generate monobrominated Trp.<ref>PMID:10941070</ref> <ref>PMID:9172332</ref> <ref>PMID:9537395</ref>
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Authors: Shepherd, S.A., Karthikeyan, C., Latham, J., Struck, A.-W., Thompson, M.L., Menon, B., Levy, C.W., Leys, D., Micklefield, J.
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==See Also==
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*[[Ribosome inactivating protein|Ribosome inactivating protein]]
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Description: F454K Mutant of Tryptophan 7-halogenase PrnA
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Thompson, M.L]]
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__TOC__
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[[Category: Micklefield, J]]
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</StructureSection>
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[[Category: Shepherd, S.A]]
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[[Category: Tryptophan 7-halogenase]]
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[[Category: Karthikeyan, C]]
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[[Category: Latham, J]]
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[[Category: Levy, C W]]
[[Category: Leys, D]]
[[Category: Leys, D]]
[[Category: Menon, B]]
[[Category: Menon, B]]
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[[Category: Latham, J]]
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[[Category: Micklefield, J]]
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[[Category: Karthikeyan, C]]
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[[Category: Shepherd, S A]]
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[[Category: Levy, C.W]]
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[[Category: Struck, A W]]
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[[Category: Struck, A.-W]]
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[[Category: Thompson, M L]]
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[[Category: Oxidoreductase]]

Revision as of 11:20, 12 May 2016

F454K Mutant of Tryptophan 7-halogenase PrnA

4z44, resolution 2.20Å

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