5c3f

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'''Unreleased structure'''
 
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The entry 5c3f is ON HOLD until Paper Publication
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==Crystal structure of Mcl-1 bound to BID-MM==
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<StructureSection load='5c3f' size='340' side='right' caption='[[5c3f]], [[Resolution|resolution]] 1.43&Aring;' scene=''>
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Authors: Miles, J.A., Yeo, D.J., Rowell, P., Rodriguez-Marin, S., Pask, C.M., Warriner, S.L., Edwards, T.A., Wilson, A.J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5c3f]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C3F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C3F FirstGlance]. <br>
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Description: Crystal structure of Mcl-1 bound to BID-MM
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene></td></tr>
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[[Category: Warriner, S.L]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c3f OCA], [http://pdbe.org/5c3f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5c3f RCSB], [http://www.ebi.ac.uk/pdbsum/5c3f PDBsum]</span></td></tr>
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[[Category: Edwards, T.A]]
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</table>
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[[Category: Wilson, A.J]]
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== Function ==
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[[Category: Pask, C.M]]
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[[http://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Edwards, T A]]
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[[Category: Miles, J A]]
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[[Category: Pask, C M]]
[[Category: Rodriguez-Marin, S]]
[[Category: Rodriguez-Marin, S]]
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[[Category: Yeo, D.J]]
 
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[[Category: Miles, J.A]]
 
[[Category: Rowell, P]]
[[Category: Rowell, P]]
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[[Category: Warriner, S L]]
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[[Category: Wilson, A J]]
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[[Category: Yeo, D J]]
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[[Category: Apoptosis]]
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[[Category: Bcl-2 family]]
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[[Category: Bh3]]
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[[Category: Complex]]
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[[Category: Stapled peptide]]

Revision as of 18:41, 12 May 2016

Crystal structure of Mcl-1 bound to BID-MM

5c3f, resolution 1.43Å

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