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5c3g

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'''Unreleased structure'''
 
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The entry 5c3g is ON HOLD until Paper Publication
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==Crystal structure of Bcl-xl bound to BIM-MM==
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<StructureSection load='5c3g' size='340' side='right' caption='[[5c3g]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
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Authors: Miles, J.A., Yeo, D.J., Rowell, P., Rodriguez-Marin, S., Pask, C.M., Warriner, S.L., Edwards, T.A., Wilson, A.J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5c3g]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C3G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C3G FirstGlance]. <br>
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Description: Crystal structure of Bcl-xl bound to BIM-MM
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c3g OCA], [http://pdbe.org/5c3g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5c3g RCSB], [http://www.ebi.ac.uk/pdbsum/5c3g PDBsum]</span></td></tr>
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[[Category: Warriner, S.L]]
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</table>
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[[Category: Edwards, T.A]]
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== Function ==
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[[Category: Wilson, A.J]]
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[[http://www.uniprot.org/uniprot/B2CL1_MOUSE B2CL1_MOUSE]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:9390687</ref> Isoform Bcl-X(S) promotes apoptosis (By similarity).<ref>PMID:9390687</ref> [[http://www.uniprot.org/uniprot/B2L11_HUMAN B2L11_HUMAN]] Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.<ref>PMID:9430630</ref> <ref>PMID:11734221</ref> <ref>PMID:12019181</ref> <ref>PMID:11997495</ref> <ref>PMID:15147734</ref> <ref>PMID:15486195</ref>
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[[Category: Pask, C.M]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Edwards, T A]]
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[[Category: Miles, J A]]
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[[Category: Pask, C M]]
[[Category: Rodriguez-Marin, S]]
[[Category: Rodriguez-Marin, S]]
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[[Category: Yeo, D.J]]
 
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[[Category: Miles, J.A]]
 
[[Category: Rowell, P]]
[[Category: Rowell, P]]
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[[Category: Warriner, S L]]
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[[Category: Wilson, A J]]
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[[Category: Yeo, D J]]
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[[Category: Apoptosis]]
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[[Category: Bcl-2 family]]
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[[Category: Bh3]]
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[[Category: Complex]]
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[[Category: Stapled peptide]]

Revision as of 18:41, 12 May 2016

Crystal structure of Bcl-xl bound to BIM-MM

5c3g, resolution 2.45Å

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