5ewr
From Proteopedia
(Difference between revisions)
m (Protected "5ewr" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==C merolae U4 snRNP protein Snu13== | |
| + | <StructureSection load='5ewr' size='340' side='right' caption='[[5ewr]], [[Resolution|resolution]] 2.35Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5ewr]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EWR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EWR FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ewr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ewr OCA], [http://pdbe.org/5ewr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ewr RCSB], [http://www.ebi.ac.uk/pdbsum/5ewr PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Structural and functional analysis of proteins involved in pre-mRNA splicing is challenging because of the complexity of the splicing machinery, known as the spliceosome. Bioinformatic, proteomic, and biochemical analyses have identified a minimal spliceosome in the red alga Cyanidioschyzon merolae. This spliceosome consists of only 40 core proteins, compared to approximately 70 in S. cerevisiae (yeast) and approximately 150 in humans. We report the X-ray crystallographic analysis of C. merolae Snu13 (CmSnu13), a key component of the assembling spliceosome, and present evidence for conservation of Snu13 function in this algal splicing pathway. The near identity of CmSnu13's three-dimensional structure to yeast and human Snu13 suggests that C. merolae should be an excellent model system for investigating the structure and function of the conserved core of the spliceosome. | ||
| - | + | Conserved structure of Snu13 from the highly reduced spliceosome of Cyanidioschyzon merolae.,Black CS, Garside EL, MacMillan AM, Rader SD Protein Sci. 2016 Apr;25(4):911-6. doi: 10.1002/pro.2894. Epub 2016 Feb 25. PMID:26833716<ref>PMID:26833716</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| + | <div class="pdbe-citations 5ewr" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Black, C]] | [[Category: Black, C]] | ||
| - | [[Category: | + | [[Category: Garside, E L]] |
| - | [[Category: | + | [[Category: MacMillan, A M]] |
[[Category: Rader, S]] | [[Category: Rader, S]] | ||
| + | [[Category: Rna binding protein]] | ||
| + | [[Category: Splicing]] | ||
Revision as of 18:44, 12 May 2016
C merolae U4 snRNP protein Snu13
| |||||||||||
