4zeg
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of TTK kinase domain in complex with a pyrazolopyrimidine inhibitor== | |
| - | + | <StructureSection load='4zeg' size='340' side='right' caption='[[4zeg]], [[Resolution|resolution]] 2.33Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4zeg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZEG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZEG FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=052:N-CYCLOPROPYL-2-METHYL-4-(7-{[2-(MORPHOLIN-4-YL)ETHYL]AMINO}-5-PHENOXYPYRAZOLO[1,5-A]PYRIMIDIN-3-YL)BENZAMIDE'>052</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zeg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zeg OCA], [http://pdbe.org/4zeg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zeg RCSB], [http://www.ebi.ac.uk/pdbsum/4zeg PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN]] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Dual-specificity kinase]] | ||
| + | [[Category: Awrey, D E]] | ||
[[Category: Battaile, K]] | [[Category: Battaile, K]] | ||
| + | [[Category: Chirgadze, N Y]] | ||
[[Category: Feher, M]] | [[Category: Feher, M]] | ||
| - | [[Category: | + | [[Category: Plotnikova, O]] |
| - | + | ||
[[Category: Qiu, W]] | [[Category: Qiu, W]] | ||
| - | [[Category: | + | [[Category: Inhibitor]] |
| + | [[Category: Kinase]] | ||
| + | [[Category: Transferase-transferase inhibitor complex]] | ||
| + | [[Category: Ttk]] | ||
Revision as of 11:58, 13 May 2016
Crystal structure of TTK kinase domain in complex with a pyrazolopyrimidine inhibitor
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