5enh

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'''Unreleased structure'''
 
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The entry 5enh is ON HOLD until Paper Publication
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==Crystal structure of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in complex with compound-12 N11528 (SGC - Diamond I04-1 fragment screening)==
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<StructureSection load='5enh' size='340' side='right' caption='[[5enh]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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Authors: Krojer, T., Talon, R., Collins, P., Bradley, A., Cox, O., Szykowska, A., Burgess-Brown, N., Brennan, P., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5enh]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ENH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ENH FirstGlance]. <br>
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Description: Crystal structure of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in complex with compound-12 N11528 (SGC -Diamond I04-1 fragment screening)
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5QB:~{N}-[(2,6-DIMETHOXYPHENYL)METHYL]ETHANAMIDE'>5QB</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5enh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5enh OCA], [http://pdbe.org/5enh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5enh RCSB], [http://www.ebi.ac.uk/pdbsum/5enh PDBsum]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/PHIP_HUMAN PHIP_HUMAN]] Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization.<ref>PMID:12242307</ref> <ref>PMID:21834987</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Arrowsmith, C H]]
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[[Category: Bountra, C]]
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[[Category: Bradley, A]]
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[[Category: Brennan, P]]
[[Category: Burgess-Brown, N]]
[[Category: Burgess-Brown, N]]
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[[Category: Krojer, T]]
 
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[[Category: Bountra, C]]
 
[[Category: Collins, P]]
[[Category: Collins, P]]
[[Category: Cox, O]]
[[Category: Cox, O]]
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[[Category: Arrowsmith, C.H]]
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[[Category: Delft, F von]]
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[[Category: Edwards, A]]
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[[Category: Krojer, T]]
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[[Category: Structural genomic]]
[[Category: Szykowska, A]]
[[Category: Szykowska, A]]
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[[Category: Von Delft, F]]
 
[[Category: Talon, R]]
[[Category: Talon, R]]
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[[Category: Bradley, A]]
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[[Category: Bromodomain]]
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[[Category: Structural Genomics Consortium (Sgc)]]
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[[Category: Crystallographic fragment screen]]
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[[Category: Edwards, A]]
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[[Category: Phip]]
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[[Category: Brennan, P]]
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[[Category: Sgc]]
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[[Category: Signaling protein]]
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[[Category: Transcription]]

Revision as of 12:03, 13 May 2016

Crystal structure of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in complex with compound-12 N11528 (SGC - Diamond I04-1 fragment screening)

5enh, resolution 1.95Å

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OCA

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