1ido
From Proteopedia
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|PDB= 1ido |SIZE=350|CAPTION= <scene name='initialview01'>1ido</scene>, resolution 1.7Å | |PDB= 1ido |SIZE=350|CAPTION= <scene name='initialview01'>1ido</scene>, resolution 1.7Å | ||
|SITE= <scene name='pdbsite=MG:Metal+Binding+Site.+This+Site+Also+Includes+GLU+314+From+...'>MG</scene> | |SITE= <scene name='pdbsite=MG:Metal+Binding+Site.+This+Site+Also+Includes+GLU+314+From+...'>MG</scene> | ||
| - | |LIGAND= <scene name='pdbligand=MG:MAGNESIUM ION'>MG</scene> | + | |LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ido FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ido OCA], [http://www.ebi.ac.uk/pdbsum/1ido PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ido RCSB]</span> | ||
}} | }} | ||
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[[Category: Lee, J O.]] | [[Category: Lee, J O.]] | ||
[[Category: Liddington, R.]] | [[Category: Liddington, R.]] | ||
| - | [[Category: MG]] | ||
[[Category: cell adhesion protein]] | [[Category: cell adhesion protein]] | ||
[[Category: cytoskeleton]] | [[Category: cytoskeleton]] | ||
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[[Category: integrin]] | [[Category: integrin]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:18:18 2008'' |
Revision as of 18:18, 30 March 2008
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| , resolution 1.7Å | |||||||
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| Sites: | |||||||
| Ligands: | |||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
I-DOMAIN FROM INTEGRIN CR3, MG2+ BOUND
Overview
We have determined the high resolution crystal structure of the A domain from the alpha chain of integrin CR3. The domain adopts a classic alpha/beta "Rossmann" fold and contains an unusual Mg2+ coordination site at its surface. One of the coordinating ligands is the glutamate side chain from another A domain molecule. We suggest that this site represents a general metal ion-dependent adhesion site (MIDAS) for binding protein ligands. We further propose that the beta subunits of integrins contain a MIDAS motif within a modified A domain. Our crystal structure will allow reliable models to be built for other members of the A domain superfamily and should facilitate development of novel adhesion modulatory drugs.
About this Structure
1IDO is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)., Lee JO, Rieu P, Arnaout MA, Liddington R, Cell. 1995 Feb 24;80(4):631-8. PMID:7867070
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