This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5e0j

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 5e0j is ON HOLD until Paper Publication
+
==1.20 A resolution structure of Norovirus 3CL protease in complex with a triazole-based macrocyclic (21-mer) inhibitor==
-
 
+
<StructureSection load='5e0j' size='340' side='right' caption='[[5e0j]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
-
Authors: Lovell, S., Battaile, K.P., Mehzabeen, N., Weerawarna, P.M., Kim, Y., Kankanamalage, A.C.G., Damalanka, V.C., Lushington, G.H., Alliston, K.R., Chang, K.-O., Groutas, W.C.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[5e0j]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E0J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E0J FirstGlance]. <br>
-
Description: 1.20 A resolution structure of Norovirus 3CL protease in complex with a triazole-based macrocyclic (21-mer) inhibitor
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5LJ:(PHENYLMETHYL)+~{N}-[(12~{S},15~{S},18~{S})-15-(CYCLOHEXYLMETHYL)-12-(HYDROXYMETHYL)-9,14,17-TRIS(OXIDANYLIDENE)-1,8,13,16,21,22-HEXAZABICYCLO[18.2.1]TRICOSA-20(23),21-DIEN-18-YL]CARBAMATE'>5LJ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5e0g|5e0g]], [[5e0h|5e0h]]</td></tr>
-
[[Category: Battaile, K.P]]
+
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calicivirin Calicivirin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.66 3.4.22.66] </span></td></tr>
-
[[Category: Weerawarna, P.M]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e0j OCA], [http://pdbe.org/5e0j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e0j RCSB], [http://www.ebi.ac.uk/pdbsum/5e0j PDBsum]</span></td></tr>
-
[[Category: Alliston, K.R]]
+
</table>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/POLG_NVN68 POLG_NVN68]] Protein p48 may play a role in viral replication by interacting with host VAPA, a vesicle-associated membrane protein that plays a role in SNARE-mediated vesicle fusion. This interaction may target replication complex to intracellular membranes.<ref>PMID:569187</ref> <ref>PMID:11160659</ref> NTPase presumably plays a role in replication. Despite having similarities with helicases, does not seem to display any helicase activity.<ref>PMID:569187</ref> <ref>PMID:11160659</ref> Protein P22 may play a role in targeting replication complex to intracellular membranes.<ref>PMID:569187</ref> <ref>PMID:11160659</ref> Viral genome-linked protein is covalently linked to the 5'-end of the positive-strand, negative-strand genomic RNAs and subgenomic RNA. Acts as a genome-linked replication primer. May recruit ribosome to viral RNA thereby promoting viral proteins translation.<ref>PMID:569187</ref> <ref>PMID:11160659</ref> 3C-like protease processes the polyprotein: 3CLpro-RdRp is first released by autocleavage, then all other proteins are cleaved. May cleave host polyadenylate-binding protein thereby inhibiting cellular translation (By similarity).<ref>PMID:569187</ref> <ref>PMID:11160659</ref> RNA-directed RNA polymerase replicates genomic and antigenomic RNA by recognizing replications specific signals. Transcribes also a subgenomic mRNA by initiating RNA synthesis internally on antigenomic RNA. This sgRNA encodes for structural proteins. Catalyzes the covalent attachment VPg with viral RNAs (By similarity).<ref>PMID:569187</ref> <ref>PMID:11160659</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Calicivirin]]
 +
[[Category: Alliston, K R]]
 +
[[Category: Battaile, K P]]
 +
[[Category: Chang, K O]]
 +
[[Category: Damalanka, V C]]
 +
[[Category: Groutas, W C]]
 +
[[Category: Kankanamalage, A C.G]]
 +
[[Category: Kim, Y]]
[[Category: Lovell, S]]
[[Category: Lovell, S]]
-
[[Category: Lushington, G.H]]
+
[[Category: Lushington, G H]]
-
[[Category: Chang, K.-O]]
+
-
[[Category: Damalanka, V.C]]
+
-
[[Category: Groutas, W.C]]
+
[[Category: Mehzabeen, N]]
[[Category: Mehzabeen, N]]
-
[[Category: Kankanamalage, A.C.G]]
+
[[Category: Weerawarna, P M]]
-
[[Category: Kim, Y]]
+
[[Category: Antiviral inhibitor]]
 +
[[Category: Cell permeable]]
 +
[[Category: Norovirus]]
 +
[[Category: Norwalk virus]]
 +
[[Category: Protease]]
 +
[[Category: Protease-protease inhibitor complex]]
 +
[[Category: Triazole macrocyclic inhibitor]]

Revision as of 19:40, 13 May 2016

1.20 A resolution structure of Norovirus 3CL protease in complex with a triazole-based macrocyclic (21-mer) inhibitor

5e0j, resolution 1.20Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5e0j"
Personal tools