5fb0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "5fb0" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 5fb0 is ON HOLD
+
==Crystal Structure of a PHD finger bound to histone H3 T3ph peptide==
-
 
+
<StructureSection load='5fb0' size='340' side='right' caption='[[5fb0]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
-
Authors: Li, H., Zhang, X.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[5fb0]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FB0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FB0 FirstGlance]. <br>
-
Description:
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
 +
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5fb1|5fb1]]</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fb0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fb0 OCA], [http://pdbe.org/5fb0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fb0 RCSB], [http://www.ebi.ac.uk/pdbsum/5fb0 PDBsum]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/SP100_HUMAN SP100_HUMAN]] Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation.<ref>PMID:11909962</ref> <ref>PMID:14647468</ref> <ref>PMID:15247905</ref> <ref>PMID:15592518</ref> <ref>PMID:15767676</ref> <ref>PMID:16177824</ref> <ref>PMID:17245429</ref> <ref>PMID:21274506</ref> <ref>PMID:21880768</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Li, H]]
[[Category: Zhang, X]]
[[Category: Zhang, X]]
-
[[Category: Li, H]]
+
[[Category: Bromodomain]]
 +
[[Category: Transcription-structural protein complex]]
 +
[[Category: Zinc finger protein]]

Revision as of 19:43, 13 May 2016

Crystal Structure of a PHD finger bound to histone H3 T3ph peptide

5fb0, resolution 2.70Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5fb0"
Personal tools