NF-kB
From Proteopedia
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<StructureSection load='1nfk' size='350' side='right' caption='Structure of mouse NF-kB1 p50 complex with DNA (PDB entry [[1nfk]])' scene=''> | <StructureSection load='1nfk' size='350' side='right' caption='Structure of mouse NF-kB1 p50 complex with DNA (PDB entry [[1nfk]])' scene=''> | ||
| - | + | == Function == | |
| - | '''NF-kB''' or '''Nuclear Factor NF-kappa''' is a DNA transcription factor. It is involved in cellular response to stimuli. NF-kB contains a Rel homology domain (RHR) which contains 2 immunoglobulin-like subdomains which interact with the major groove of DNA. There are 5 proteins in the NF-kB family: '''NF-kB1''' (synthesized as '''p105''' and processed to '''p50''') | + | '''NF-kB''' or '''Nuclear Factor NF-kappa''' is a DNA transcription factor. It is involved in cellular response to stimuli. NF-kB contains a Rel homology domain (RHR) which contains 2 immunoglobulin-like subdomains which interact with the major groove of DNA<ref>PMID:15371334</ref>. I-κ-B-α is an inhibitor of NF-kB.<br /> |
| + | There are 5 proteins in the NF-kB family:<br /> | ||
| + | *'''NF-kB1''' (synthesized as '''p105''' and processed to '''p50''')<br /> | ||
| + | *'''NF-kB2''' (synthesized as '''p100''' and processed to '''p52''')<br /> | ||
| + | *'''RelA''' (or '''p65''')<br /> | ||
| + | *'''RelB'''<br /> | ||
| + | *'''cRel'''. | ||
| + | |||
| + | == Relevance == | ||
| + | NF-kB plays a critical role in cancer development and progression and may determine its response to therapy. NF-kB is a target for chemotherapeutic agents<ref>PMID:16673382</ref>. | ||
</StructureSection> | </StructureSection> | ||
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**[[3jv4]] – hp105 dimerization domain + RelB dimerization domain<br /> | **[[3jv4]] – hp105 dimerization domain + RelB dimerization domain<br /> | ||
}} | }} | ||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 06:46, 15 May 2016
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3D structures of NF-kappaB
Updated on 15-May-2016
References
- ↑ Hayden MS, Ghosh S. Signaling to NF-kappaB. Genes Dev. 2004 Sep 15;18(18):2195-224. PMID:15371334 doi:http://dx.doi.org/10.1101/gad.1228704
- ↑ Karin M. NF-kappaB and cancer: mechanisms and targets. Mol Carcinog. 2006 Jun;45(6):355-61. PMID:16673382 doi:http://dx.doi.org/10.1002/mc.20217
