1ieo
From Proteopedia
| Line 4: | Line 4: | ||
|PDB= 1ieo |SIZE=350|CAPTION= <scene name='initialview01'>1ieo</scene> | |PDB= 1ieo |SIZE=350|CAPTION= <scene name='initialview01'>1ieo</scene> | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=NH2:AMINO GROUP'>NH2</scene> | + | |LIGAND= <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1ien|1IEN]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ieo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ieo OCA], [http://www.ebi.ac.uk/pdbsum/1ieo PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ieo RCSB]</span> | ||
}} | }} | ||
| Line 32: | Line 35: | ||
[[Category: Sharpe, I A.]] | [[Category: Sharpe, I A.]] | ||
[[Category: Thomas, L.]] | [[Category: Thomas, L.]] | ||
| - | [[Category: NH2]] | ||
[[Category: conotoxin]] | [[Category: conotoxin]] | ||
[[Category: neuronal noradrenaline transporter]] | [[Category: neuronal noradrenaline transporter]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:18:49 2008'' |
Revision as of 18:18, 30 March 2008
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| Ligands: | , | ||||||
| Related: | 1IEN
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
SOLUTION STRUCTURE OF MRIB-NH2
Overview
Cone snails use venom containing a cocktail of peptides ('conopeptides') to capture their prey. Many of these peptides also target mammalian receptors, often with exquisite selectivity. Here we report the discovery of two new classes of conopeptides. One class targets alpha1-adrenoceptors (rho-TIA from the fish-hunting Conus tulipa), and the second class targets the neuronal noradrenaline transporter (chi-MrIA and chi-MrIB from the mollusk-hunting C. marmoreus). rho-TIA and chi-MrIA selectively modulate these important membrane-bound proteins. Both peptides act as reversible non-competitive inhibitors and provide alternative avenues for the identification of inhibitor drugs.
About this Structure
1IEO is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.
Reference
Two new classes of conopeptides inhibit the alpha1-adrenoceptor and noradrenaline transporter., Sharpe IA, Gehrmann J, Loughnan ML, Thomas L, Adams DA, Atkins A, Palant E, Craik DJ, Adams DJ, Alewood PF, Lewis RJ, Nat Neurosci. 2001 Sep;4(9):902-7. PMID:11528421
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