1ih2
From Proteopedia
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|PDB= 1ih2 |SIZE=350|CAPTION= <scene name='initialview01'>1ih2</scene>, resolution 2.8Å | |PDB= 1ih2 |SIZE=350|CAPTION= <scene name='initialview01'>1ih2</scene>, resolution 2.8Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=CBR:5-BROMO-2'-DEOXY-CYTIDINE-5'-MONOPHOSPHATE'>CBR</scene>, <scene name='pdbligand=DC:2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE'>DG</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1ih1|1IH1]], [[1ih3|1IH3]], [[1ih4|1IH4]], [[1ih6|1IH6]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ih2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ih2 OCA], [http://www.ebi.ac.uk/pdbsum/1ih2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ih2 RCSB]</span> | ||
}} | }} | ||
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[[Category: structural transition]] | [[Category: structural transition]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:19:39 2008'' |
Revision as of 18:19, 30 March 2008
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| , resolution 2.8Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , | ||||||
| Related: | 1IH1, 1IH3, 1IH4, 1IH6
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of GGBr5CGBr5CC
Overview
The transition between B- and A-DNA was first observed nearly 50 years ago. We have now mapped this transformation through a set of single-crystal structures of the sequence d(GGCGCC)2, with various intermediates being trapped by methylating or brominating the cytosine bases. The resulting pathway progresses through 13 conformational steps, with a composite structure that pairs A-nucleotides with complementary B-nucleotides serving as a distinct transition intermediate. The details of each step in the conversion of B- to A-DNA are thus revealed at the atomic level, placing intermediates for this and other sequences in the context of a common pathway.
About this Structure
1IH2 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
A crystallographic map of the transition from B-DNA to A-DNA., Vargason JM, Henderson K, Ho PS, Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7265-70. Epub 2001 Jun 5. PMID:11390969
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