1ij9
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ij9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ij9 OCA], [http://www.ebi.ac.uk/pdbsum/1ij9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ij9 RCSB]</span> | ||
}} | }} | ||
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==Overview== | ==Overview== | ||
An X-ray crystal structure of two N-terminal integrin-binding IgSF domains of human VCAM-1 is reported. This new crystal form shows an unusual and highly hydrated packing arrangement in which over 80% of the crystal is occupied by solvent. The relative orientations of the two domains adopt a new intermediate conformation. The tilt angle between the two domains is 19.4 degrees, compared with other related structures that have tilt angles ranging from 7.3 to 39.9 degrees. An analysis of the torsion angles shows that residues Ile88, Tyr89, Ser90, Pro92 and Glu96 play a major role in defining the interdomain conformations. | An X-ray crystal structure of two N-terminal integrin-binding IgSF domains of human VCAM-1 is reported. This new crystal form shows an unusual and highly hydrated packing arrangement in which over 80% of the crystal is occupied by solvent. The relative orientations of the two domains adopt a new intermediate conformation. The tilt angle between the two domains is 19.4 degrees, compared with other related structures that have tilt angles ranging from 7.3 to 39.9 degrees. An analysis of the torsion angles shows that residues Ile88, Tyr89, Ser90, Pro92 and Glu96 play a major role in defining the interdomain conformations. | ||
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| - | ==Disease== | ||
| - | Known diseases associated with this structure: CRASH syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=308840 308840]], Corpus callosum, partial agenesis of OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=308840 308840]], Hydrocephalus due to aqueductal stenosis OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=308840 308840]], Hydrocephalus with Hirschsprung disease and cleft palate OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=308840 308840]], Hydrocephalus with congenital idiopathic intestinal pseudoobstruction OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=308840 308840]], MASA syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=308840 308840]] | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: integrin solvation]] | [[Category: integrin solvation]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:20:38 2008'' |
Revision as of 18:20, 30 March 2008
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| , resolution 3.00Å | |||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Highly Hydrated Human VCAM-1 Fragment
Overview
An X-ray crystal structure of two N-terminal integrin-binding IgSF domains of human VCAM-1 is reported. This new crystal form shows an unusual and highly hydrated packing arrangement in which over 80% of the crystal is occupied by solvent. The relative orientations of the two domains adopt a new intermediate conformation. The tilt angle between the two domains is 19.4 degrees, compared with other related structures that have tilt angles ranging from 7.3 to 39.9 degrees. An analysis of the torsion angles shows that residues Ile88, Tyr89, Ser90, Pro92 and Glu96 play a major role in defining the interdomain conformations.
About this Structure
1IJ9 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
A new conformation of the integrin-binding fragment of human VCAM-1 crystallizes in a highly hydrated packing arrangement., Taylor P, Bilsland M, Walkinshaw MD, Acta Crystallogr D Biol Crystallogr. 2001 Nov;57(Pt 11):1579-83. Epub 2001, Oct 25. PMID:11679722
Page seeded by OCA on Sun Mar 30 21:20:38 2008
