1ik3
From Proteopedia
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|PDB= 1ik3 |SIZE=350|CAPTION= <scene name='initialview01'>1ik3</scene>, resolution 2.0Å | |PDB= 1ik3 |SIZE=350|CAPTION= <scene name='initialview01'>1ik3</scene>, resolution 2.0Å | ||
|SITE= <scene name='pdbsite=FE3:Fe+(Fe+3)+Active+Site'>FE3</scene> | |SITE= <scene name='pdbsite=FE3:Fe+(Fe+3)+Active+Site'>FE3</scene> | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=11O:(TRANS-12,13-EPOXY)-11-HYDROXY-9(Z)-OCTADECENOIC+ACID'>11O</scene>, <scene name='pdbligand=13R:13(R)-HYDROPEROXY-9(Z),11(E)-OCTADECADIENOIC+ACID'>13R</scene>, <scene name='pdbligand=13S:13(S)-HYDROPEROXY-9(Z),11(E)-OCTADECADIENOIC+ACID'>13S</scene>, <scene name='pdbligand=9OH:(TRANS-12,13-EPOXY)-9-HYDROXY-10(E)-OCTADECENOIC+ACID'>9OH</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Lipoxygenase Lipoxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.12 1.13.11.12] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Lipoxygenase Lipoxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.12 1.13.11.12] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ik3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ik3 OCA], [http://www.ebi.ac.uk/pdbsum/1ik3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ik3 RCSB]</span> | ||
}} | }} | ||
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[[Category: Jr., M O.Funk.]] | [[Category: Jr., M O.Funk.]] | ||
[[Category: Skrzypczak-Jankun, E.]] | [[Category: Skrzypczak-Jankun, E.]] | ||
| - | [[Category: 11O]] | ||
| - | [[Category: 13R]] | ||
| - | [[Category: 13S]] | ||
| - | [[Category: 9OH]] | ||
| - | [[Category: FE]] | ||
[[Category: fe(iii) complex]] | [[Category: fe(iii) complex]] | ||
[[Category: interm]] | [[Category: interm]] | ||
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[[Category: purple lipoxygenase]] | [[Category: purple lipoxygenase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:20:51 2008'' |
Revision as of 18:20, 30 March 2008
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| , resolution 2.0Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | |||||||
| Ligands: | , , , , | ||||||
| Activity: | Lipoxygenase, with EC number 1.13.11.12 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
LIPOXYGENASE-3 (SOYBEAN) COMPLEX WITH 13(S)-HYDROPEROXY-9(Z),11(E)-OCTADECADIENOIC ACID
Overview
Polyunsaturated fatty acid metabolism is governed primarily by two enzymes, prostaglandin H synthase and lipoxygenase. The crystal structure of the metastable product-oxidized purple form of soybean lipoxygenase-3 was determined at 2.0 A resolution. The data reveal that the chromophore corresponds to an iron-peroxide complex, a potential intermediate in the catalyzed reaction. A significant alteration of the iron site accompanies the formation of the complex. The structure, the first for a fatty acid-lipoxygenase complex, also reveals an unexpected mode of binding, and identifies amino acid residues that may play significant roles in catalysis, regio- and stereoselectivity.
About this Structure
1IK3 is a Single protein structure of sequence from Glycine max. Full crystallographic information is available from OCA.
Reference
Three-dimensional structure of a purple lipoxygenase., Skrzypczak-Jankun E, Bross RA, Carroll RT, Dunham WR, Funk MO Jr, J Am Chem Soc. 2001 Nov 7;123(44):10814-20. PMID:11686682
Page seeded by OCA on Sun Mar 30 21:20:51 2008
