5b3j
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Activation of NMDA receptors and the mechanism of inhibition by ifenprodil== | |
| - | + | <StructureSection load='5b3j' size='340' side='right' caption='[[5b3j]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5b3j]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B3J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5B3J FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5b3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b3j OCA], [http://pdbe.org/5b3j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5b3j RCSB], [http://www.ebi.ac.uk/pdbsum/5b3j PDBsum]</span></td></tr> |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NMDE2_RAT NMDE2_RAT]] NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Diaz-Avalos, R]] | ||
[[Category: Furukawa, H]] | [[Category: Furukawa, H]] | ||
| - | [[Category: Diaz-Avalos, R]] | ||
[[Category: Grant, T]] | [[Category: Grant, T]] | ||
| + | [[Category: Grigorieff, N]] | ||
| + | [[Category: Karakas, E]] | ||
[[Category: Simorowski, N]] | [[Category: Simorowski, N]] | ||
| - | [[Category: | + | [[Category: Tajima, N]] |
| - | [[Category: | + | [[Category: Nmda receptor]] |
| + | [[Category: Transport protein]] | ||
Revision as of 17:04, 15 May 2016
Activation of NMDA receptors and the mechanism of inhibition by ifenprodil
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