1im2
From Proteopedia
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|PDB= 1im2 |SIZE=350|CAPTION= <scene name='initialview01'>1im2</scene>, resolution 2.80Å | |PDB= 1im2 |SIZE=350|CAPTION= <scene name='initialview01'>1im2</scene>, resolution 2.80Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5'-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1g41|1G41]], [[1do0|1DO0]], [[1do2|1DO2]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1im2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1im2 OCA], [http://www.ebi.ac.uk/pdbsum/1im2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1im2 RCSB]</span> | ||
}} | }} | ||
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[[Category: McKay, D B.]] | [[Category: McKay, D B.]] | ||
[[Category: Trame, C B.]] | [[Category: Trame, C B.]] | ||
| - | [[Category: ADP]] | ||
| - | [[Category: SO4]] | ||
[[Category: aaa family]] | [[Category: aaa family]] | ||
[[Category: chaperone]] | [[Category: chaperone]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:21:34 2008'' |
Revision as of 18:21, 30 March 2008
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| , resolution 2.80Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , | ||||||
| Related: | 1G41, 1DO0, 1DO2
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
HslU, Haemophilus Influenzae, Selenomethionine Variant
Overview
The structure of the Haemophilus influenzae HslU protein, a molecular chaperone of the Clp/Hsp100 family, has been solved to 2.3 A by molecular replacement using a model of the homologous Escherichia coli protein. The crystals in which the structure was solved have an unusual twinning, or one-dimensional disorder, in which each successive crystal-packing layer is displaced laterally relative to the one below it. A model for the twinning and an algorithm for detwinning the data are described. It is known from other work that when the HslU hexamer binds its cognate protease HslV, the carboxy-terminal helices of HslU protomers distend and bind between HslV subunits. Comparison of HslU alone with its structure in the HslUV complex reveals several conserved amino-acid residues whose side-chain interactions differ between the two structures, suggesting that they may be part of a conformational switch that facilitates the release of the HslU carboxy-terminal helices when HslV binds.
About this Structure
1IM2 is a Single protein structure of sequence from Haemophilus influenzae. Full crystallographic information is available from OCA.
Reference
Structure of Haemophilus influenzae HslU protein in crystals with one-dimensional disorder twinning., Trame CB, McKay DB, Acta Crystallogr D Biol Crystallogr. 2001 Aug;57(Pt 8):1079-90. Epub 2001, Jul 23. PMID:11468391
Page seeded by OCA on Sun Mar 30 21:21:34 2008
