5ii0
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the human calcitonin receptor ectodomain in complex with a truncated salmon calcitonin analogue== | |
| - | + | <StructureSection load='5ii0' size='340' side='right' caption='[[5ii0]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5ii0]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5II0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5II0 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=URE:UREA'>URE</scene></td></tr> | |
| - | [[ | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=4BF:4-BROMO-L-PHENYLALANINE'>4BF</scene>, <scene name='pdbligand=LPD:L-PROLINAMIDE'>LPD</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ii0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ii0 OCA], [http://pdbe.org/5ii0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ii0 RCSB], [http://www.ebi.ac.uk/pdbsum/5ii0 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CALCR_HUMAN CALCR_HUMAN]] This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Johansson, E]] | [[Category: Johansson, E]] | ||
[[Category: Reedtz-Runge, S]] | [[Category: Reedtz-Runge, S]] | ||
| + | [[Category: Calcitonin]] | ||
| + | [[Category: Ectodomain]] | ||
| + | [[Category: G protein coupled receptor]] | ||
| + | [[Category: Hormone]] | ||
| + | [[Category: Peptide hormone]] | ||
Revision as of 17:12, 15 May 2016
Crystal structure of the human calcitonin receptor ectodomain in complex with a truncated salmon calcitonin analogue
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