Nuclear receptor coactivator
From Proteopedia
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*'''NCOA1''' shows histone acetyltransferase activity and is required for steroid hormone response.<br /> | *'''NCOA1''' shows histone acetyltransferase activity and is required for steroid hormone response.<br /> | ||
*'''NCOA2''' is a DNA transcription coactivator with glucocorticoid receptor.<br /> | *'''NCOA2''' is a DNA transcription coactivator with glucocorticoid receptor.<br /> | ||
| - | *'''NCOA3''' shows histone acetyltransferase activity. | + | *'''NCOA3''' shows histone acetyltransferase activity.<br /> |
| + | *'''NCOA5''' is both a DNA transcription coactivator and corepressor. It interacts with steroid receptor.<br /> | ||
==3D structures of nuclear receptor coactivator== | ==3D structures of nuclear receptor coactivator== | ||
Revision as of 08:39, 16 May 2016
Nuclear receptor coactivator (NCOA) is a protein recruited by nuclear receptors in order to enhance or repress DNA transcription. NCOA is involved in coactivation with transcription factors[1].
- NCOA1 shows histone acetyltransferase activity and is required for steroid hormone response.
- NCOA2 is a DNA transcription coactivator with glucocorticoid receptor.
- NCOA3 shows histone acetyltransferase activity.
- NCOA5 is both a DNA transcription coactivator and corepressor. It interacts with steroid receptor.
3D structures of nuclear receptor coactivator
1v95 – hNCOA5 – human - NMR
1kbh – hNCOA + CREB-binding protein - NMR
2c52 – hNCOA1 residues 920-970 + CREB-binding protein - NMR
1oj5 – NCOA1A Pas-B domain + signal transducer and activator of transcription peptide - mouse
References
- ↑ Horwitz KB, Jackson TA, Bain DL, Richer JK, Takimoto GS, Tung L. Nuclear receptor coactivators and corepressors. Mol Endocrinol. 1996 Oct;10(10):1167-77. PMID:9121485 doi:http://dx.doi.org/10.1210/mend.10.10.9121485
