Nuclear transcription factor Y

From Proteopedia

Revision as of 10:35, 16 May 2016

spinqualitylabelsall models Human nuclear transcription factor Y subunit α (cyan), subunit β (green) and subunit γ (deeppink) complex with HSP70 promoter fragment (PDB code 4awl) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Nuclear transcription factor Y (NFY) binds to a CCAAT sequence of gene promoters. NFY contains 3 subunits while subunit α binds the promoter box sequence[1]. See details in NF-Y Transcription Factor. Relevance NFY is a regulatory factor for many genes which are overexpressed in many kinds of cancer[2]. Structural highlights (PDB code 4awl). The interaction of NFY with the promoter CCAAT sequence, involves an insertion of an NFY helix into the minor groove of the DNA[3].

3D Structures of nuclear transcription factor Y

Updated on 16-May-2016

1n1j, 4csr – hNFY β+γ subunits - human
4awl – hNFY α+β+γ subunits + promoter DNA

References

1. ↑ Maity SN, de Crombrugghe B. Role of the CCAAT-binding protein CBF/NF-Y in transcription. Trends Biochem Sci. 1998 May;23(5):174-8. PMID:9612081
2. ↑ Bargou RC, Jurchott K, Wagener C, Bergmann S, Metzner S, Bommert K, Mapara MY, Winzer KJ, Dietel M, Dorken B, Royer HD. Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression. Nat Med. 1997 Apr;3(4):447-50. PMID:9095180
3. ↑ Nardini M, Gnesutta N, Donati G, Gatta R, Forni C, Fossati A, Vonrhein C, Moras D, Romier C, Bolognesi M, Mantovani R. Sequence-Specific Transcription Factor NF-Y Displays Histone-like DNA Binding and H2B-like Ubiquitination. Cell. 2013 Jan 17;152(1-2):132-43. doi: 10.1016/j.cell.2012.11.047. PMID:23332751 doi:http://dx.doi.org/10.1016/j.cell.2012.11.047