User:Brittany Stankavich/Sandbox 2
From Proteopedia
(Difference between revisions)
(New page: ==Glucocorticoid Receptor== <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> This is a default text for your page '''Brittany Stankavich...) |
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You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
| - | == | + | == Glucose Homeostasis == |
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| + | Glucocorticoids (GC) are involved extensively in the regulation of physiological glucose levels. | ||
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| + | === Gluconeogenesis === | ||
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| + | Gluconeogenesis occurs mainly in the liver to generate glucose from non-carbohydrate substrates such as lactate, glycerol, and gluconeogenic amino acids such as alanine. [[insert pathway]] | ||
| + | GC increase the activity of gluconeogenesis in hepatic cells predominantly by activating the transcription of genes encoding gluconeogenic enzymes such as pyruvate carboxylase (PC), cytosolic phosphoenolpyruvate carboxykinase (PCK1), fructose-1,6-bisphosphatase 1 (FBP1), phosphofructokinase 2/fructose bisphosphatase 2 complex (PFKFB1), glucose-6-phosphatase catalytic subunit (G6PC), and glucose-6-phosophate (G6P) transporter. GC coordinate with an intracellular glucocorticoid receptor (GR) to signal transcription. Prior to the GC/GR binding however, GR is complexed with a chaperone Hsp90 in the cytoplasm. Upon binding of the GC to the GR, the GR/Hsp90 complex dissociates where | ||
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== Disease == | == Disease == | ||
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== Structural highlights == | == Structural highlights == | ||
| - | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 14:29, 26 May 2016
Glucocorticoid Receptor
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
