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JMS/Sandbox21
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<StructureSection load='3fhi' size='340' side='right' caption='Caption for this structure' scene='58/583419/3fhi/1'> | <StructureSection load='3fhi' size='340' side='right' caption='Caption for this structure' scene='58/583419/3fhi/1'> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <scene name='58/583419/Pka_reg/1'>The PKA catalytic unit crystalized with | + | <scene name='58/583419/Pka_reg/1'>The PKA catalytic unit crystalized with its regulatory unit</scene>, pdb structure [[3fhi]]<ref>PMID:15692043</ref>, is shown with the catalytic unit's small lobe in ''gray'' and large lobe in ''tan'', and the regulatory unit in ''light blue''. |
There is <scene name='58/583419/Pka_reg/4'>significant distance from the regulatory unit's residues to the residues from exon 1 of the catalytic unit</scene>. Here the residues which interact with the regulatory unit '''R''' are represent with halos and ball-and-stick. The residues from the catalytic unit's ''exon 1'' are labelled by residue index. Note that the last three residues from exon 1 (residues # 13-15) are the only amino acids from the first exon of the catalytic unit that were included in this crystal structure. | There is <scene name='58/583419/Pka_reg/4'>significant distance from the regulatory unit's residues to the residues from exon 1 of the catalytic unit</scene>. Here the residues which interact with the regulatory unit '''R''' are represent with halos and ball-and-stick. The residues from the catalytic unit's ''exon 1'' are labelled by residue index. Note that the last three residues from exon 1 (residues # 13-15) are the only amino acids from the first exon of the catalytic unit that were included in this crystal structure. | ||
Revision as of 17:13, 29 May 2016
PKA and Regulators
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References
- ↑ Kim C, Xuong NH, Taylor SS. Crystal structure of a complex between the catalytic and regulatory (RIalpha) subunits of PKA. Science. 2005 Feb 4;307(5710):690-6. PMID:15692043 doi:307/5710/690
- ↑ Zheng J, Trafny EA, Knighton DR, Xuong NH, Taylor SS, Ten Eyck LF, Sowadski JM. 2.2 A refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MnATP and a peptide inhibitor. Acta Crystallogr D Biol Crystallogr. 1993 May 1;49(Pt 3):362-5. PMID:15299527 doi:10.1107/S0907444993000423
