5fk9
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of staphylococcal enterotoxin A F47A mutant in complex with a T cell receptor== | |
| + | <StructureSection load='5fk9' size='340' side='right' caption='[[5fk9]], [[Resolution|resolution]] 3.10Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5fk9]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FK9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FK9 FirstGlance]. <br> | ||
| + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5fka|5fka]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fk9 OCA], [http://pdbe.org/5fk9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fk9 RCSB], [http://www.ebi.ac.uk/pdbsum/5fk9 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ETXA_STAAU ETXA_STAAU]] Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness is characterized by high fever, hypotension, diarrhea, shock, and in some cases death. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Superantigens are toxins produced by Staphylococcus aureus, called staphylococcal enterotoxins (abbreviated SEA to SEU). They can cross-link the T cell receptor (TCR) and major histocompatibility complex class II, triggering a massive T cell activation and hence disease. Due to high stability and toxicity, superantigens are potential agents of bioterrorism. Hence, antagonists may not only be useful in the treatment of disease but also serve as countermeasures to biological warfare. Of particular interest are inhibitors against SEA and SEB. SEA is the main cause of food poisoning, while SEB is a common toxin manufactured as a biological weapon. Here, we present the crystal structures of SEA in complex with TCR and SEE in complex with the same TCR, complemented with computational alanine-scanning mutagenesis of SEA, SEB, SEC3, SEE, and SEH. We have identified two common areas that contribute to the general TCR binding for these superantigens. This paves the way for design of single antagonists directed towards multiple toxins. | ||
| - | + | Two common structural motifs for TCR recognition by staphylococcal enterotoxins.,Rodstrom KE, Regenthal P, Bahl C, Ford A, Baker D, Lindkvist-Petersson K Sci Rep. 2016 May 16;6:25796. doi: 10.1038/srep25796. PMID:27180909<ref>PMID:27180909</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| + | <div class="pdbe-citations 5fk9" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Lindkvist-Petersson, K]] | [[Category: Lindkvist-Petersson, K]] | ||
| - | [[Category: Rodstrom, K.E.J]] | ||
[[Category: Regenthal, P]] | [[Category: Regenthal, P]] | ||
| + | [[Category: Rodstrom, K E.J]] | ||
| + | [[Category: Immune system]] | ||
| + | [[Category: Major histocompatibility complex]] | ||
| + | [[Category: Staphylcococcal enterotoxin]] | ||
| + | [[Category: Superantigen]] | ||
| + | [[Category: T cell receptor]] | ||
Revision as of 07:40, 1 June 2016
Crystal structure of staphylococcal enterotoxin A F47A mutant in complex with a T cell receptor
| |||||||||||
