1iqo
From Proteopedia
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| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1iqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iqo OCA], [http://www.ebi.ac.uk/pdbsum/1iqo PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1iqo RCSB]</span> | ||
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[[Category: structural genomic]] | [[Category: structural genomic]] | ||
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Revision as of 18:23, 30 March 2008
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Solution structure of MTH1880 from methanobacterium thermoautotrophicum
Overview
MTH1880 is a hypothetical protein from Methanobacterium thermoautotrophicum, a target organism of structural genomics. The solution structure determined by NMR spectroscopy demonstrates a typical alpha + beta-fold found in many proteins with different functions. The molecular surface of the protein reveals a small, highly acidic pocket comprising loop B (Asp36, Asp37, Asp38), the end of beta2 (Glu39), and loop D (Ser57, Ser58, Ser61), indicating that the protein would have a possible cation binding site. The NMR resonances of several amino acids within the acidic binding pocket in MTH1880, shifted upon addition of calcium ion. This calcium binding motif and overall topology of MTH1880 differ from those of other calcium binding proteins. MTH1880 did not show a calcium-induced conformational change typical of calcium sensor proteins. Therefore, we propose that the MTH1880 protein contains a novel motif for calcium-specific binding, and may function as a calcium buffering protein.
About this Structure
1IQO is a Single protein structure of sequence from Methanothermobacter. Full crystallographic information is available from OCA.
Reference
Solution structure of a novel calcium binding protein, MTH1880, from Methanobacterium thermoautotrophicum., Lee CH, Jung JW, Yee A, Arrowsmith CH, Lee W, Protein Sci. 2004 Apr;13(4):1148-54. PMID:15044740
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