1irj
From Proteopedia
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|PDB= 1irj |SIZE=350|CAPTION= <scene name='initialview01'>1irj</scene>, resolution 2.10Å | |PDB= 1irj |SIZE=350|CAPTION= <scene name='initialview01'>1irj</scene>, resolution 2.10Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> | + | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CPS:3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE'>CPS</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1irj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1irj OCA], [http://www.ebi.ac.uk/pdbsum/1irj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1irj RCSB]</span> | ||
}} | }} | ||
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[[Category: Watanabe, N.]] | [[Category: Watanabe, N.]] | ||
[[Category: Yao, M.]] | [[Category: Yao, M.]] | ||
| - | [[Category: CA]] | ||
| - | [[Category: CPS]] | ||
[[Category: calgranulin b]] | [[Category: calgranulin b]] | ||
[[Category: ef-hand]] | [[Category: ef-hand]] | ||
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[[Category: s100a9]] | [[Category: s100a9]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:23:37 2008'' |
Revision as of 18:23, 30 March 2008
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| , resolution 2.10Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of the MRP14 complexed with CHAPS
Overview
Human MRP14 (hMRP14) is a Ca(2+)-binding protein from the S100 family of proteins. This protein is co-expressed with human MRP8 (hMRP8), a homologue protein in myeloid cells, and plays an indispensable role in Ca(2+)-dependent functions during inflammation. This role includes the activation of Mac-1, the beta(2) integrin which is involved in neutrophil adhesion to endothelial cells. The crystal structure of the holo form of hMRP14 was analyzed at 2.1 A resolution. hMRP14 is distinguished from other S100 member proteins by its long C-terminal region, and its structure shows that the region is extensively flexible. In this crystal structure of hMRP14, Chaps molecules bind to the hinge region that connects two EF-hand motifs, which suggests that this region is a target-binding site of this protein. Based on a structural comparison of hMRP14 with hMRP8 and human S100A12 (hS100A12) that is another homologue protein, the character of MRP8/14 hetero-complex and the functional significance of the flexibility of the C-terminal region of hMRP14 are discussed.
About this Structure
1IRJ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The crystal structure of human MRP14 (S100A9), a Ca(2+)-dependent regulator protein in inflammatory process., Itou H, Yao M, Fujita I, Watanabe N, Suzuki M, Nishihira J, Tanaka I, J Mol Biol. 2002 Feb 15;316(2):265-76. PMID:11851337
Page seeded by OCA on Sun Mar 30 21:23:37 2008
Categories: Homo sapiens | Single protein | Itou, H. | Nishihira, J. | Tanaka, I. | Watanabe, N. | Yao, M. | Calgranulin b | Ef-hand | Mrp14 | S100a9
