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1iuc
From Proteopedia
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|PDB= 1iuc |SIZE=350|CAPTION= <scene name='initialview01'>1iuc</scene>, resolution 2.24Å | |PDB= 1iuc |SIZE=350|CAPTION= <scene name='initialview01'>1iuc</scene>, resolution 2.24Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1iub|1IUB]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1iuc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iuc OCA], [http://www.ebi.ac.uk/pdbsum/1iuc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1iuc RCSB]</span> | ||
}} | }} | ||
| Line 28: | Line 31: | ||
[[Category: Peapus, D H.]] | [[Category: Peapus, D H.]] | ||
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]] | [[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]] | ||
| - | [[Category: FUC]] | ||
| - | [[Category: FUL]] | ||
| - | [[Category: SO4]] | ||
[[Category: lectin]] | [[Category: lectin]] | ||
[[Category: riken structural genomics/proteomics initiative]] | [[Category: riken structural genomics/proteomics initiative]] | ||
| Line 36: | Line 36: | ||
[[Category: structural genomic]] | [[Category: structural genomic]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:24:45 2008'' |
Revision as of 18:24, 30 March 2008
| |||||||
| , resolution 2.24Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , | ||||||
| Related: | 1IUB
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Fucose-specific lectin from Aleuria aurantia with three ligands
Overview
Aleuria aurantia possesses a fucose-specific lectin (AAL) that is widely used as a specific probe for fucose. Fucosylated sugars often play pivotal roles in many cellular processes. We have determined the crystal structure of AAL at 2.24 A resolution in complex with only three fucose molecules in its five sugar binding sites of a six-fold beta-propeller structure. Very recently, the structure of AAL has been independently determined, showing that all the five binding sites were occupied by fucose molecules [Wimmerova, M., et al. (2003) J. Biol. Chem. 278, 27059-27067]. Stabilization of the arginine conformation bound to fucose molecules plays an essential role in generating the difference in the affinity in the five binding sites. Binding models with a couple of saccharides based on biochemical assays suggest that hydrophobic contacts also play important roles in AAL recognizing its ligand.
About this Structure
1IUC is a Single protein structure of sequence from Aleuria aurantia. Full crystallographic information is available from OCA.
Reference
Crystal structure of fucose-specific lectin from Aleuria aurantia binding ligands at three of its five sugar recognition sites., Fujihashi M, Peapus DH, Kamiya N, Nagata Y, Miki K, Biochemistry. 2003 Sep 30;42(38):11093-9. PMID:14503859
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