1iy2
From Proteopedia
| Line 4: | Line 4: | ||
|PDB= 1iy2 |SIZE=350|CAPTION= <scene name='initialview01'>1iy2</scene>, resolution 3.2Å | |PDB= 1iy2 |SIZE=350|CAPTION= <scene name='initialview01'>1iy2</scene>, resolution 3.2Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene> | + | |LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= FtsH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus]) | |GENE= FtsH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1ixz|1IXZ]], [[1iy0|1IY0]], [[1iy1|1IY1]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1iy2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iy2 OCA], [http://www.ebi.ac.uk/pdbsum/1iy2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1iy2 RCSB]</span> | ||
}} | }} | ||
| Line 27: | Line 30: | ||
[[Category: Tsuchiya, D.]] | [[Category: Tsuchiya, D.]] | ||
[[Category: Yoshida, M.]] | [[Category: Yoshida, M.]] | ||
| - | [[Category: SO4]] | ||
[[Category: aaa domain fold]] | [[Category: aaa domain fold]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:26:13 2008'' |
Revision as of 18:26, 30 March 2008
| |||||||
| , resolution 3.2Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | FtsH (Thermus thermophilus) | ||||||
| Related: | 1IXZ, 1IY0, 1IY1
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of the FtsH ATPase domain from Thermus thermophilus
Overview
FtsH is a cytoplasmic membrane-integrated, ATP-dependent metalloprotease, which processively degrades both cytoplasmic and membrane proteins in concert with unfolding. The FtsH protein is divided into the N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. We have determined the crystal structures of the Thermus thermophilus FtsH ATPase domain in the nucleotide-free and AMP-PNP- and ADP-bound states, in addition to the domain with the extra preceding segment. Combined with the mapping of the putative substrate binding region, these structures suggest that FtsH internally forms a hexameric ring structure, in which ATP binding could cause a conformational change to facilitate transport of substrates into the protease domain through the central pore.
About this Structure
1IY2 is a Single protein structure of sequence from Thermus thermophilus. Full crystallographic information is available from OCA.
Reference
Hexameric ring structure of the ATPase domain of the membrane-integrated metalloprotease FtsH from Thermus thermophilus HB8., Niwa H, Tsuchiya D, Makyio H, Yoshida M, Morikawa K, Structure. 2002 Oct;10(10):1415-23. PMID:12377127
Page seeded by OCA on Sun Mar 30 21:26:13 2008
