5bnm
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==E. coli FabH with Small Molecule Inhibitor 1== | |
| - | + | <StructureSection load='5bnm' size='340' side='right' caption='[[5bnm]], [[Resolution|resolution]] 1.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5bnm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BNM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BNM FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4VK:N-{[3-(HYDROXYMETHYL)BIPHENYL-4-YL]METHYL}BENZENESULFONAMIDE'>4VK</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5bnr|5bnr]], [[5bns|5bns]], [[5bqs|5bqs]]</td></tr> |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-ketoacyl-[acyl-carrier-protein]_synthase_III Beta-ketoacyl-[acyl-carrier-protein] synthase III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.180 2.3.1.180] </span></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bnm OCA], [http://pdbe.org/5bnm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bnm RCSB], [http://www.ebi.ac.uk/pdbsum/5bnm PDBsum]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/FABH_ECOLI FABH_ECOLI]] Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Has some substrate specificity for acetyl-CoA. Its substrate specificity determines the biosynthesis of straight-chain of fatty acids instead of branched-chain.[HAMAP-Rule:MF_01815] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Kazmirski, S L]] | ||
| + | [[Category: McKinney, D C]] | ||
| + | [[Category: Bacterial enzyme]] | ||
| + | [[Category: Fabh]] | ||
| + | [[Category: Fatty acid synthesis]] | ||
| + | [[Category: Transferase-transferase inhibitor complex]] | ||
Revision as of 15:48, 1 June 2016
E. coli FabH with Small Molecule Inhibitor 1
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