4zy3
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of Keap1 in Complex with a small chemical compound, K67== | |
| - | + | <StructureSection load='4zy3' size='340' side='right' caption='[[4zy3]], [[Resolution|resolution]] 1.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4zy3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZY3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZY3 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=K67:N,N-[2-(2-OXOPROPYL)NAPHTHALENE-1,4-DIYL]BIS(4-ETHOXYBENZENESULFONAMIDE)'>K67</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zy3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zy3 OCA], [http://pdbe.org/4zy3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zy3 RCSB], [http://www.ebi.ac.uk/pdbsum/4zy3 PDBsum]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/KEAP1_MOUSE KEAP1_MOUSE]] Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (By similarity).<ref>PMID:9887101</ref> <ref>PMID:12682069</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Fukutomi, T]] | ||
[[Category: Iso, T]] | [[Category: Iso, T]] | ||
| - | [[Category: Yamamoto, M]] | ||
| - | [[Category: Fukutomi, T]] | ||
[[Category: Komatsu, M]] | [[Category: Komatsu, M]] | ||
[[Category: Mizushima, T]] | [[Category: Mizushima, T]] | ||
[[Category: Suzuki, T]] | [[Category: Suzuki, T]] | ||
[[Category: Takagi, K]] | [[Category: Takagi, K]] | ||
| + | [[Category: Yamamoto, M]] | ||
| + | [[Category: Double glycine repeat]] | ||
| + | [[Category: Keap1]] | ||
| + | [[Category: Kelch domain]] | ||
| + | [[Category: Nrf2]] | ||
| + | [[Category: P62]] | ||
| + | [[Category: Small molecule binding]] | ||
| + | [[Category: Stress sensor]] | ||
| + | [[Category: Transcription]] | ||
Revision as of 22:52, 1 June 2016
Crystal Structure of Keap1 in Complex with a small chemical compound, K67
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Categories: Fukutomi, T | Iso, T | Komatsu, M | Mizushima, T | Suzuki, T | Takagi, K | Yamamoto, M | Double glycine repeat | Keap1 | Kelch domain | Nrf2 | P62 | Small molecule binding | Stress sensor | Transcription
