5fyq
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Sirt2 in complex with a 13-mer trifluoroacetylated Ran peptide== | |
| - | + | <StructureSection load='5fyq' size='340' side='right' caption='[[5fyq]], [[Resolution|resolution]] 3.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5fyq]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FYQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FYQ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[ | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAK:N~6~-(TRIFLUOROACETYL)-L-LYSINE'>FAK</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fyq OCA], [http://pdbe.org/5fyq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fyq RCSB], [http://www.ebi.ac.uk/pdbsum/5fyq PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SIR2_HUMAN SIR2_HUMAN]] NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and non-histone proteins. Deacetylates 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Deacetylates PCK1, opposing proteasomal degradation. Deacetylates 'Lys-310' of RELA.<ref>PMID:12620231</ref> <ref>PMID:12697818</ref> <ref>PMID:21081649</ref> <ref>PMID:21726808</ref> [[http://www.uniprot.org/uniprot/RAN_HUMAN RAN_HUMAN]] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Baldus, L]] | [[Category: Baldus, L]] | ||
| + | [[Category: Baumann, U]] | ||
| + | [[Category: Boor, S de]] | ||
[[Category: Extra, A]] | [[Category: Extra, A]] | ||
| - | [[Category: Scislowski, L]] | ||
[[Category: Knyphausen, P]] | [[Category: Knyphausen, P]] | ||
| + | [[Category: Lammers, M]] | ||
[[Category: Neundorf, I]] | [[Category: Neundorf, I]] | ||
| - | [[Category: De Boor, S]] | ||
| - | [[Category: Baumann, U]] | ||
[[Category: Schacherl, M]] | [[Category: Schacherl, M]] | ||
| - | [[Category: | + | [[Category: Scislowski, L]] |
| + | [[Category: Genetic-code expansion]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Kdac]] | ||
| + | [[Category: Lysine-acetylation]] | ||
| + | [[Category: Lysine-deacetylase]] | ||
| + | [[Category: Sirtuin]] | ||
Revision as of 22:58, 1 June 2016
Sirt2 in complex with a 13-mer trifluoroacetylated Ran peptide
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