5irz

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "5irz" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 5irz is ON HOLD
+
==Structure of TRPV1 determined in lipid nanodisc==
-
 
+
<StructureSection load='5irz' size='340' side='right' caption='[[5irz]], [[Resolution|resolution]] 3.28&Aring;' scene=''>
-
Authors: Gao, Y., Cao, E., Julius, D., Cheng, Y.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[5irz]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IRZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IRZ FirstGlance]. <br>
-
Description: Structure of TRPV1 determined in lipid nanodisc
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6ES:(2S)-1-{[(R)-HYDROXY{[(1R,2R,3S,4S,5S,6S)-2,3,4,5,6-PENTAHYDROXYCYCLOHEXYL]OXY}PHOSPHORYL]OXY}-3-(PENTANOYLOXY)PROPAN-2-YL+DECANOATE'>6ES</scene>, <scene name='pdbligand=6O8:(4R,7S)-4-HYDROXY-N,N,N-TRIMETHYL-4,9-DIOXO-7-[(PENTANOYLOXY)METHYL]-3,5,8-TRIOXA-4LAMBDA~5~-PHOSPHATETRADECAN-1-AMINIUM'>6O8</scene>, <scene name='pdbligand=6OE:(2S)-3-{[(S)-(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-2-(HEXANOYLOXY)PROPYL+HEXANOATE'>6OE</scene></td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5irx|5irx]], [[5is0|5is0]]</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5irz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5irz OCA], [http://pdbe.org/5irz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5irz RCSB], [http://www.ebi.ac.uk/pdbsum/5irz PDBsum]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/TRPV1_RAT TRPV1_RAT]] Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis.<ref>PMID:9349813</ref> <ref>PMID:10644739</ref> <ref>PMID:11140687</ref> <ref>PMID:11418861</ref> <ref>PMID:12095983</ref> <ref>PMID:12194871</ref> <ref>PMID:12808128</ref> <ref>PMID:14523239</ref> <ref>PMID:12764195</ref> <ref>PMID:14630912</ref> <ref>PMID:15173182</ref> <ref>PMID:21076423</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Cao, E]]
[[Category: Cheng, Y]]
[[Category: Cheng, Y]]
 +
[[Category: Gao, Y]]
[[Category: Julius, D]]
[[Category: Julius, D]]
-
[[Category: Gao, Y]]
+
[[Category: Ion channel]]
-
[[Category: Cao, E]]
+
[[Category: Lipid]]
 +
[[Category: Nanodisc]]
 +
[[Category: Transport protein]]
 +
[[Category: Trp]]
 +
[[Category: Vanilloid]]

Revision as of 23:02, 1 June 2016

Structure of TRPV1 determined in lipid nanodisc

5irz, resolution 3.28Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5irz"
Personal tools