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5is0

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m (Protected "5is0" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5is0 is ON HOLD
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==Structure of TRPV1 in complex with capsazepine, determined in lipid nanodisc==
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<StructureSection load='5is0' size='340' side='right' caption='[[5is0]], [[Resolution|resolution]] 3.43&Aring;' scene=''>
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Authors: Gao, Y., Cao, E., Julius, D., Cheng, Y.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5is0]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IS0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IS0 FirstGlance]. <br>
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Description: Structure of TRPV1 in complex with capsazepine, determined in lipid nanodisc
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6ET:CAPSAZEPINE'>6ET</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5irx|5irx]], [[5irz|5irz]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5is0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5is0 OCA], [http://pdbe.org/5is0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5is0 RCSB], [http://www.ebi.ac.uk/pdbsum/5is0 PDBsum]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/TRPV1_RAT TRPV1_RAT]] Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis.<ref>PMID:9349813</ref> <ref>PMID:10644739</ref> <ref>PMID:11140687</ref> <ref>PMID:11418861</ref> <ref>PMID:12095983</ref> <ref>PMID:12194871</ref> <ref>PMID:12808128</ref> <ref>PMID:14523239</ref> <ref>PMID:12764195</ref> <ref>PMID:14630912</ref> <ref>PMID:15173182</ref> <ref>PMID:21076423</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Cao, E]]
[[Category: Cheng, Y]]
[[Category: Cheng, Y]]
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[[Category: Gao, Y]]
[[Category: Julius, D]]
[[Category: Julius, D]]
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[[Category: Gao, Y]]
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[[Category: Interaction]]
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[[Category: Cao, E]]
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[[Category: Ion channel]]
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[[Category: Lipid]]
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[[Category: Nanodisc]]
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[[Category: Transport protein]]
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[[Category: Trp]]
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[[Category: Vanilloid]]

Revision as of 23:02, 1 June 2016

Structure of TRPV1 in complex with capsazepine, determined in lipid nanodisc

5is0, resolution 3.43Å

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