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4zw2

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'''Unreleased structure'''
 
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The entry 4zw2 is ON HOLD until Paper Publication
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==Crystal structure of the Mouse voltage gated calcium channel beta subunit isoform 1a in complex with Alpha Interaction Domain peptide.==
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<StructureSection load='4zw2' size='340' side='right' caption='[[4zw2]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
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Authors: Norris, N.C., Oakley, A.J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4zw2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZW2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZW2 FirstGlance]. <br>
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Description: Crystal structure of the Mouse voltage gated calcium channel beta subunit isoform 1a in complex with Alpha Interaction Domain peptide.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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[[Category: Norris, N.C]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zw2 OCA], [http://pdbe.org/4zw2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zw2 RCSB], [http://www.ebi.ac.uk/pdbsum/4zw2 PDBsum]</span></td></tr>
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[[Category: Oakley, A.J]]
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/CAC1S_MOUSE CAC1S_MOUSE]] Defects in Cacna1s are the cause of muscular dysgenesis (MDG), a lethal autosomal recessive disorder in which there is total lack of excitation-contraction coupling in homozygotes, and which results in complete skeletal muscle paralysis. A single nucleotide deletion yields a protein with an altered and truncated C-terminus.<ref>PMID:1281468</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/CACB1_MOUSE CACB1_MOUSE]] The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. [[http://www.uniprot.org/uniprot/CAC1S_MOUSE CAC1S_MOUSE]] Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Norris, N C]]
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[[Category: Oakley, A J]]
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[[Category: Alpha interacting domain]]
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[[Category: Cavbeta]]
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[[Category: Dihydropyridine receptor]]
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[[Category: Excitation contraction coupling]]
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[[Category: Metal transport]]

Revision as of 06:03, 2 June 2016

Crystal structure of the Mouse voltage gated calcium channel beta subunit isoform 1a in complex with Alpha Interaction Domain peptide.

4zw2, resolution 1.86Å

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