5cy0
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Total Chemical Synthesis, Covalent Structure Verification, and X-ray Structure of Bioactive Ts3 Toxin by Racemic Protein Crystallography== | |
| - | + | <StructureSection load='5cy0' size='340' side='right' caption='[[5cy0]], [[Resolution|resolution]] 1.93Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5cy0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CY0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CY0 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cy0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cy0 OCA], [http://pdbe.org/5cy0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cy0 RCSB], [http://www.ebi.ac.uk/pdbsum/5cy0 PDBsum]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SCX3_TITSE SCX3_TITSE]] Binds voltage-dependently at site-3 of sodium channels (Nav) and inhibits the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin is active against mammals (mice).<ref>PMID:15051403</ref> <ref>PMID:15249424</ref> <ref>PMID:2536799</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Bezanilla, F]] | [[Category: Bezanilla, F]] | ||
| - | [[Category: | + | [[Category: Correa, A M]] |
[[Category: Dang, B]] | [[Category: Dang, B]] | ||
| + | [[Category: Kent, S B]] | ||
| + | [[Category: Kubota, T]] | ||
[[Category: Mandal, K]] | [[Category: Mandal, K]] | ||
| - | [[Category: | + | [[Category: Central symmetric]] |
| - | [[Category: | + | [[Category: Nav ligand]] |
| + | [[Category: Racemic structure]] | ||
| + | [[Category: Toxin]] | ||
Revision as of 06:06, 2 June 2016
Total Chemical Synthesis, Covalent Structure Verification, and X-ray Structure of Bioactive Ts3 Toxin by Racemic Protein Crystallography
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Categories: Bezanilla, F | Correa, A M | Dang, B | Kent, S B | Kubota, T | Mandal, K | Central symmetric | Nav ligand | Racemic structure | Toxin
