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5dmi
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the extracellular domain of the CD40 in complex with CHI220 FAB== | |
| - | + | <StructureSection load='5dmi' size='340' side='right' caption='[[5dmi]], [[Resolution|resolution]] 3.69Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5dmi]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DMI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DMI FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[ | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5dmj|5dmj]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dmi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dmi OCA], [http://pdbe.org/5dmi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dmi RCSB], [http://www.ebi.ac.uk/pdbsum/5dmi PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/TNR5_HUMAN TNR5_HUMAN]] Defects in CD40 are the cause of immunodeficiency with hyper-IgM type 3 (HIGM3) [MIM:[http://omim.org/entry/606843 606843]]. A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections.<ref>PMID:11675497</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TNR5_HUMAN TNR5_HUMAN]] Receptor for TNFSF5/CD40LG. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Sheriff, S]] | [[Category: Sheriff, S]] | ||
| + | [[Category: Antibody-antigen complex]] | ||
| + | [[Category: Antitumor]] | ||
| + | [[Category: Cell surface receptor]] | ||
| + | [[Category: Immune system-signaling protein complex]] | ||
Revision as of 06:06, 2 June 2016
Structure of the extracellular domain of the CD40 in complex with CHI220 FAB
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