5dmj

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'''Unreleased structure'''
 
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The entry 5dmj is ON HOLD until Paper Publication
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==Structure of the extracellular domain of the CD40 in complex with 3H56-5 DAB==
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<StructureSection load='5dmj' size='340' side='right' caption='[[5dmj]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
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Authors: Sheriff, S.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5dmj]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DMJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DMJ FirstGlance]. <br>
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Description: Structure of the extracellular domain of the CD40 in complex with 3H56-5 DAB
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5dmi|5dmi]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dmj OCA], [http://pdbe.org/5dmj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dmj RCSB], [http://www.ebi.ac.uk/pdbsum/5dmj PDBsum]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/TNR5_HUMAN TNR5_HUMAN]] Defects in CD40 are the cause of immunodeficiency with hyper-IgM type 3 (HIGM3) [MIM:[http://omim.org/entry/606843 606843]]. A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections.<ref>PMID:11675497</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/TNR5_HUMAN TNR5_HUMAN]] Receptor for TNFSF5/CD40LG.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Sheriff, S]]
[[Category: Sheriff, S]]
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[[Category: Cell surface receptor]]
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[[Category: Domain antibody]]
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[[Category: Immune system-signaling protein complex]]
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[[Category: Protein/protein interaction]]

Revision as of 06:06, 2 June 2016

Structure of the extracellular domain of the CD40 in complex with 3H56-5 DAB

5dmj, resolution 2.79Å

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