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Eukaryotic initiation factor
From Proteopedia
(Difference between revisions)
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| - | <StructureSection load='1ipb' size=' | + | <StructureSection load='1ipb' size='450' side='right' scene='50/507723/Cv/1' caption='Human initiation factor EIF4E complex with 7-methyl GPPPA [[1ipb]]'> |
== Function == | == Function == | ||
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== Structural insights == | == Structural insights == | ||
| - | EIF domains include the N terminal domain (NTD), C terminal domain (CTD), RNA recognition domain, middle domain, PAZ domain of EIF2C and a protein-protein interaction domain (PCI) of EIF3. | + | EIF domains include the N terminal domain (NTD), C terminal domain (CTD), RNA recognition domain, middle domain, PAZ domain of EIF2C and a protein-protein interaction domain (PCI) of EIF3. |
| + | |||
| + | *<scene name='50/507723/Cv/3'>P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE (7-methyl GPPPA) binding site</scene>. Water molecules shown as red spheres. | ||
</StructureSection> | </StructureSection> | ||
Revision as of 08:16, 6 June 2016
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3D structures of eukaryotic initiation factor
Updated on 06-June-2016
References
- ↑ Jivotovskaya AV, Valasek L, Hinnebusch AG, Nielsen KH. Eukaryotic translation initiation factor 3 (eIF3) and eIF2 can promote mRNA binding to 40S subunits independently of eIF4G in yeast. Mol Cell Biol. 2006 Feb;26(4):1355-72. PMID:16449648 doi:http://dx.doi.org/10.1128/MCB.26.4.1355-1372.2006
- ↑ Hershey JW. The role of eIF3 and its individual subunits in cancer. Biochim Biophys Acta. 2015 Jul;1849(7):792-800. doi:, 10.1016/j.bbagrm.2014.10.005. Epub 2014 Nov 1. PMID:25450521 doi:http://dx.doi.org/10.1016/j.bbagrm.2014.10.005
