Nucleoporin
From Proteopedia
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{{STRUCTURE_1xip| PDB=1xip | SIZE=300| SCENE=Nucleoporin/Cv/1 |right|CAPTION=yeast Nucleoporin NUP159, [[1xip]] }} | {{STRUCTURE_1xip| PDB=1xip | SIZE=300| SCENE=Nucleoporin/Cv/1 |right|CAPTION=yeast Nucleoporin NUP159, [[1xip]] }} | ||
[[Nucleoporin|Nucleoporins]] (NUP) are constituents of the nuclear pore complex which regulates the flow of macromolecules across the nuclear envelope. They are named according to their molecular weights. They contain a domain which binds the protein RAN (RANBD), N-terminal domain (NTD) and C-terminal domain (CTD)<ref>PMID:9159086</ref>. <br /> | [[Nucleoporin|Nucleoporins]] (NUP) are constituents of the nuclear pore complex which regulates the flow of macromolecules across the nuclear envelope. They are named according to their molecular weights. They contain a domain which binds the protein RAN (RANBD), N-terminal domain (NTD) and C-terminal domain (CTD)<ref>PMID:9159086</ref>. <br /> | ||
| - | *NUP1P is a yeast nucleoprotein required for nuclear protein import, mRNA export and maintenance of nuclear architecture<ref>PMID:8045927</ref>. <br /> | + | *'''NUP1P''' is a yeast nucleoprotein required for nuclear protein import, mRNA export and maintenance of nuclear architecture<ref>PMID:8045927</ref>. <br /> |
| - | *NUP2P is a yeast nucleoprotein required for bidirectional transport of importin α<ref>PMID:11046143</ref>. <br /> | + | *'''NUP2P''' is a yeast nucleoprotein required for bidirectional transport of importin α<ref>PMID:11046143</ref>. <br /> |
| + | *'''NUP Gle1''' is a yeast and human nucleoprotein required mRNA export. <br /> | ||
== 3D Structures of Nucleoporin == | == 3D Structures of Nucleoporin == | ||
Revision as of 08:56, 6 June 2016
Template:STRUCTURE 1xip
Nucleoporins (NUP) are constituents of the nuclear pore complex which regulates the flow of macromolecules across the nuclear envelope. They are named according to their molecular weights. They contain a domain which binds the protein RAN (RANBD), N-terminal domain (NTD) and C-terminal domain (CTD)[1].
- NUP1P is a yeast nucleoprotein required for nuclear protein import, mRNA export and maintenance of nuclear architecture[2].
- NUP2P is a yeast nucleoprotein required for bidirectional transport of importin α[3].
- NUP Gle1 is a yeast and human nucleoprotein required mRNA export.
3D Structures of Nucleoporin
Updated on 06-June-2016
References
- ↑ Doye V, Hurt E. From nucleoporins to nuclear pore complexes. Curr Opin Cell Biol. 1997 Jun;9(3):401-11. PMID:9159086
- ↑ Belanger KD, Kenna MA, Wei S, Davis LI. Genetic and physical interactions between Srp1p and nuclear pore complex proteins Nup1p and Nup2p. J Cell Biol. 1994 Aug;126(3):619-30. PMID:8045927
- ↑ Solsbacher J, Maurer P, Vogel F, Schlenstedt G. Nup2p, a yeast nucleoporin, functions in bidirectional transport of importin alpha. Mol Cell Biol. 2000 Nov;20(22):8468-79. PMID:11046143
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