P63

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== Function ==
== Function ==
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'''P63''' is a tumor protein belonging to the P53 family. It is a multi-isoform protein required for epidermal development<ref>PMID:10594758</ref>. One isoform of P63 is involved in skin development and stem/progenitor cell regulation. Another isoform functions in apoptosis. P63 domains structure is similar to that of P53 with an N-terminal transactivation domain (TAD) followed by proline-rich region, DNA-binding domain (DBD) and tetramerization domain. In addition, the P63 contains an additional C-terminal region with SAM (Sterile a-Motif) and transactivation inhibitory domains. The SAM domain is involved in protein-protein interactions.
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'''P63''' is a tumor protein belonging to the P53 family. It is a multi-isoform protein required for epidermal development<ref>PMID:10594758</ref>. P63 domains structure is similar to that of P53 with an N-terminal transactivation domain (TAD) followed by proline-rich region, DNA-binding domain (DBD) and tetramerization domain. In addition, the P63 contains an additional C-terminal region with SAM (Sterile a-Motif) and transactivation inhibitory domains. The SAM domain is involved in protein-protein interactions.
== Disease ==
== Disease ==
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== Relevance ==
== Relevance ==
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== Structural highlights ==
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One isoform of P63 is involved in skin development and stem/progenitor cell regulation<ref>PMID:17224652</ref>. Another isoform functions in apoptosis<ref>PMID:16998800</ref>.
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</StructureSection>

Revision as of 10:05, 13 June 2016

P63 DNA-binding domain complex with DNA and Zn+2 atoms (grey) (PDB code 3us0)

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3D Structures of P63

Updated on 13-June-2016

References

  1. ↑ Parsa R, Yang A, McKeon F, Green H. Association of p63 with proliferative potential in normal and neoplastic human keratinocytes. J Invest Dermatol. 1999 Dec;113(6):1099-105. PMID:10594758 doi:http://dx.doi.org/10.1046/j.1523-1747.1999.00780.x
  2. ↑ Leoyklang P, Siriwan P, Shotelersuk V. A mutation of the p63 gene in non-syndromic cleft lip. J Med Genet. 2006 Jun;43(6):e28. PMID:16740912 doi:43/6/e28
  3. ↑ Tadini G, Santagada F, Brena M, Pezzani L, Nannini P. Ectodermal dysplasias: the p63 tail. G Ital Dermatol Venereol. 2013 Feb;148(1):53-8. PMID:23407076
  4. ↑ Koster MI, Dai D, Roop DR. Conflicting roles for p63 in skin development and carcinogenesis. Cell Cycle. 2007 Feb 1;6(3):269-73. Epub 2007 Feb 3. PMID:17224652 doi:http://dx.doi.org/10.4161/cc.6.3.3792
  5. ↑ Petre-Lazar B, Livera G, Moreno SG, Trautmann E, Duquenne C, Hanoux V, Habert R, Coffigny H. The role of p63 in germ cell apoptosis in the developing testis. J Cell Physiol. 2007 Jan;210(1):87-98. PMID:16998800 doi:http://dx.doi.org/10.1002/jcp.20829

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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